Cirrhosis-associated immune dysfunction

A Albillos, R Martin-Mateos, S Van der Merwe… - Nature Reviews …, 2022 - nature.com
The term cirrhosis-associated immune dysfunction (CAID) comprises the distinctive
spectrum of immune alterations associated with the course of end-stage liver disease …

Crosstalk between oxidative stress and inflammatory liver injury in the pathogenesis of alcoholic liver disease

YM Yang, YE Cho, S Hwang - International journal of molecular sciences, 2022 - mdpi.com
Alcoholic liver disease (ALD) is characterized by the injury, inflammation, and scarring in the
liver owing to excessive alcohol consumption. Currently, ALD is a leading cause for liver …

EASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosis

P Angeli, M Bernardi, C Villanueva, C Francoz… - Journal of …, 2018 - Elsevier
The natural history of cirrhosis is characterised by an asymptomatic compensated phase
followed by a decompensated phase, marked by the development of overt clinical signs, the …

Albumin in decompensated cirrhosis: new concepts and perspectives

M Bernardi, P Angeli, J Claria, R Moreau, P Gines… - Gut, 2020 - gut.bmj.com
The pathophysiological background of decompensated cirrhosis is characterised by a
systemic proinflammatory and pro-oxidant milieu that plays a major role in the development …

Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis

R Moreau, R Jalan, P Gines, M Pavesi, P Angeli… - Gastroenterology, 2013 - Elsevier
BACKGROUND & AIMS: Patients with cirrhosis hospitalized for an acute decompensation
(AD) and organ failure are at risk for imminent death and considered to have acute-on …

[HTML][HTML] Bacterial infections in cirrhosis: a position statement based on the EASL Special Conference 2013

R Jalan, J Fernandez, R Wiest, B Schnabl… - Journal of …, 2014 - Elsevier
Bacterial infections are very common and represent one of the most important reasons of
progression of liver failure, development of liver-related complications, and mortality in …

Role of the inflammasome in acetaminophen-induced liver injury and acute liver failure

BL Woolbright, H Jaeschke - Journal of hepatology, 2017 - Elsevier
Drug-induced acute liver failure carries a high morbidity and mortality rate. Acetaminophen
overdose is the number one cause of acute liver failure and remains a major problem in …

Acute-on-chronic liver failure: terminology, mechanisms and management

SK Sarin, A Choudhury - Nature Reviews Gastroenterology & …, 2016 - nature.com
Acute-on-chronic liver failure (ACLF) is a distinct clinical entity and differs from acute liver
failure and decompensated cirrhosis in timing, presence of acute precipitant, course of …

Neutrophils in liver diseases: pathogenesis and therapeutic targets

K Liu, FS Wang, R Xu - Cellular & molecular immunology, 2021 - nature.com
Previously, it was assumed that peripheral neutrophils are a homogeneous population that
displays antimicrobial functions. However, recent data have revealed that neutrophils are …

Interleukin‐1 and inflammasomes in alcoholic liver disease/acute alcoholic hepatitis and nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

H Tilg, AR Moschen, G Szabo - Hepatology, 2016 - journals.lww.com
Both alcoholic liver disease (ALD) and nonalcoholic fatty liver disease are characterized by
massive lipid accumulation in the liver accompanied by inflammation, fibrosis, cirrhosis, and …