The complement cascade comprises soluble and cell surface proteins and is an important
arm of the innate immune system. Once activated, the complement system rapidly generates …

Anti–glomerular basement membrane (anti-GBM) disease is a rare small vessel vasculitis
that affects the capillary beds of the kidneys and lungs. It is an archetypic autoimmune …

Background Coronavirus disease 2019 (COVID-19) is thought to cause kidney injury by a
variety of mechanisms. To date, pathologic analyses have been limited to patient reports …

The kidneys are frequently targeted by pathogenic immune responses against renal
autoantigens or by local manifestations of systemic autoimmunity. Recent studies in rodent …

The immune system and the kidneys are closely linked. In health the kidneys contribute to
immune homeostasis, while components of the immune system mediate many acute forms …

Most glomerulonephritides, even the more common types, are rare diseases. They are
nevertheless important since they frequently affect young people, often cannot be cured, and …

Co-presentation with both ANCA and anti-GBM antibodies is thought to be relatively rare.
Current studies of such 'double-positive'cases report small numbers and variable outcomes …

Background Idiopathic membranous nephropathy is a major cause of the nephrotic
syndrome in adults, but its etiologic basis is not fully understood. We investigated the genetic …

This document follows up on a 2017 revised international consensus on anti-neutrophil
cytoplasm antibodies (ANCA) testing in granulomatosis with polyangiitis and microscopic …

The cellular microenvironment, characterized by an extracellular matrix (ECM), played an
essential role in the transition from unicellularity to multicellularity in animals (metazoans) …