Nanocarrier‐mediated cytosolic delivery of biopharmaceuticals

W He, X **ng, X Wang, D Wu, W Wu… - Advanced functional …, 2020 - Wiley Online Library
Biopharmaceuticals have emerged to play a vital role in disease treatment and have shown
promise in the rapidly expanding pharmaceutical market due to their high specificity and …

Impact of nanoparticles on amyloid peptide and protein aggregation: a review with a focus on gold nanoparticles

T John, A Gladytz, C Kubeil, LL Martin, HJ Risselada… - Nanoscale, 2018 - pubs.rsc.org
Society is increasingly exposed to nanoparticles as they are ubiquitous in nature and
introduced as man-made air pollutants and as functional ingredients in cosmetic products as …

COVID-19 diagnosis by SARS-CoV-2 Spike protein detection in saliva using an ultrasensitive magneto-assay based on disposable electrochemical sensor

ED Nascimento, WT Fonseca, TR de Oliveira… - Sensors and Actuators B …, 2022 - Elsevier
The outbreak of the COVID-19 pandemic, caused by Severe Acute Respiratory Syndrome of
Coronavirus 2 (SARS-CoV-2), has fueled the search for diagnostic tests aiming at the control …

Melimine-modified 3D-printed polycaprolactone scaffolds for the prevention of biofilm-related biomaterial infections

S Cometta, RT Jones, A Juárez-Saldivar, BC Donose… - ACS …, 2022 - ACS Publications
Biomaterial-associated infections are one of the major causes of implant failure. These
infections result from persistent bacteria that have adhered to the biomaterial surface before …

[HTML][HTML] Unravelling the physicochemical and antimicrobial mechanisms of human serum albumin/tannic acid coatings for medical-grade polycaprolactone scaffolds

S Cometta, BC Donose, A Juárez-Saldivar… - Bioactive Materials, 2024 - Elsevier
Biofilm-related biomaterial infections are notoriously challenging to treat and can lead to
chronic infection and persisting inflammation. To date, a large body of research can be …

Peptide Self‐Assembly into Amyloid Fibrils at Hard and Soft Interfaces—From Corona Formation to Membrane Activity

T John, LL Martin, B Abel - Macromolecular Bioscience, 2023 - Wiley Online Library
Peptides and proteins are exposed to a variety of interfaces in a physiological environment,
such as cell membranes, protein nanoparticles (NPs), or viruses. These interfaces have a …

Dual-stage blue-light-guided membrane and DNA-targeted photodynamic inactivation using octyl gallate for ultraefficient eradication of planktonic bacteria and sessile …

Y Shi, S Lin, W Chen, L Jiang, Q Gu, D Li… - Journal of Agricultural …, 2022 - ACS Publications
This study aimed to investigate the synergistic bactericidal activity and mechanism of dual-
stage light-guided membrane and DNA-targeted photodynamic inactivation (PDI) by the …

Lipid oxidation controls peptide self-assembly near membranes through a surface attraction mechanism

T John, S Piantavigna, TJA Dealey, B Abel… - Chemical …, 2023 - pubs.rsc.org
The self-assembly of peptides into supramolecular structures has been linked to
neurodegenerative diseases but has also been observed in functional roles. Peptides are …

Adsorption of amyloidogenic peptides to functionalized surfaces is biased by charge and hydrophilicity

T John, GW Greene, NA Patil, TJA Dealey… - Langmuir, 2019 - ACS Publications
Surfaces are abundant in living systems, such as in the form of cellular membranes, and
govern many biological processes. In this study, the adsorption of the amyloidogenic model …

[HTML][HTML] Biophysical characterization of LTX-315 anticancer peptide interactions with model membrane platforms: effect of membrane surface charge

DJ Koo, TN Sut, SW Tan, BK Yoon… - International Journal of …, 2022 - mdpi.com
LTX-315 is a clinical-stage, anticancer peptide therapeutic that disrupts cancer cell
membranes. Existing mechanistic knowledge about LTX-315 has been obtained from cell …