Macrophages play pivotal roles in immunity, hematopoiesis, and tissue homeostasis. In
mammals, macrophages have been shown to originate from yolk-sac-derived erythro …

Little is known about the mechanisms regulating the transition of circulating monocytes into
pro-or anti-inflammatory macrophages in chronic inflammation. Here, we took advantage of …

The transcription factor forkhead box O1 (FOXO1), which instructs the dark zone program to
direct germinal center (GC) polarity, is typically inactivated by phosphatidylinositol 3-kinase …

Genetic variation influences how the genome is interpreted in individuals and in mouse
strains used to model immune responses. We developed approaches to utilize next …

We have reported that hematopoietic system injury induced by total body irradiation (TBI)
leads to generation of intracellular reactive oxygen species (ROS) and DNA damage, which …

Defective reactive oxygen species (ROS) production by genetically determined variants of
the NADPH oxidase 2 (NOX2) complex component, NCF4, leads to enhanced production of …

Adoptive cell transfer between genetically identical hosts relies on the use of a congenic
marker to distinguish the donor cells from the host cells. CD45, a glycoprotein expressed by …

Allelic variants of the pan-haematopoietic cell marker CD45, identified as CD45. 1 and
CD45. 2, have been established as a marker system to track haematopoietic cells following …

α4β7 integrin is a cell adhesion receptor that is crucial for the migration of hematopoietic
progenitors and mature effector cells in the periphery, but its role in adult hematopoiesis is …

Eosinophils are frequently elevated in pathological conditions and can cause tissue damage
and disease exacerbation. The number of eosinophils in the blood is largely regulated by …