Immune alterations in the intrauterine environment shapes offspring brain development in a sex-specific manner

E Guma, MM Chakravarty - Biological Psychiatry, 2024 - Elsevier
Exposure to inflammation in utero or in early life is known to increase risk for
neuropsychiatric illness. The sources of inflammation can be varied, including acute …

[HTML][HTML] Altered brain metabolites in male nonhuman primate offspring exposed to maternal immune activation

RJ Maddock, RM Vlasova, S Chen, AM Iosif… - Brain, Behavior, and …, 2024 - Elsevier
Converging data show that exposure to maternal immune activation (MIA) in utero alters
brain development in animals and increases the risk of neurodevelopmental disorders in …

Excessive interstitial free-water in cortical gray matter preceding accelerated volume changes in individuals at clinical high risk for psychosis

KIK Cho, F Zhang, N Penzel, J Seitz-Holland… - Molecular …, 2024 - nature.com
Recent studies show that accelerated cortical gray matter (GM) volume reduction seen in
anatomical MRI can help distinguish between individuals at clinical high risk (CHR) for …

Maternal prenatal immune activation associated with brain tissue microstructure and metabolite concentrations in newborn infants

MN Spann, R Bansal, E Aydin, A Pollatou… - Brain, Behavior, and …, 2024 - Elsevier
Few human studies have assessed the association of prenatal maternal immune activation
(MIA) with measures of brain development and psychiatric risk in newborn offspring. Our …

Genetic Associations Among Inflammation, White Matter Architecture, and Extracellular Free Water

AL Rodrigue, EEM Knowles, J Mollon, SR Mathias… - 2025 - Wiley Online Library
Phenotypic and genetic relationships between white matter microstructure (ie, fractional
anisotropy [FA]) and peripheral inflammatory responses (ie, circulating cytokines) have …

Elevated Extracellular Free Water in the Brain Predicts Clinical Improvement in First-Episode Psychosis

TA Lesh, D Bergé, J Smucny, J Guo… - Biological Psychiatry …, 2025 - Elsevier
Background Despite the diverse nature of clinical trajectories after a first episode of
psychosis, few baseline characteristics have been predictive of clinical improvement, and …

IL-6 Enhances the Activation of PI3K-AKT/mTOR-GSK-3β by Upregulating GRPR in Hippocampal Neurons of Autistic Mice

H Li, X Wang, C Hu, J Cui, H Li, X Luo… - Journal of Neuroimmune …, 2024 - Springer
Autism spectrum disorder (ASD) is a neurological disorder associated with brain
inflammation. The underlying mechanisms could be attributed to the activation of PI3K …

Inhibitory systems in brain evolution: pathways of vulnerability in neurodevelopmental disorders

KL Hanson, DMZ Greiner, CM Schumann… - Brain Behavior and …, 2024 - karger.com
Background: The evolution of the primate brain has been characterized by the
reorganization of key structures and circuits underlying derived specializations in sensory …

Altered Extracellular Matrix Structure and Elevated Stiffness in a Brain Organoid Model for Disease

MK Zur, B Bhattacharya, SB Dror, I Solomonov… - bioRxiv, 2024 - biorxiv.org
The viscoelasticity of tissues impacts their shape, as well as the growth and differentiation of
their cells. Nevertheless, little is known about changes in viscoelastic properties during brain …

[PDF][PDF] Altered Extracellular Matrix Structure and Elevated Stiffness in a Brain Organoid Model for Disease

MK Zur, B Bhattacharya, SB Dror, I Solomonov… - 2024 - scholar.archive.org
The viscoelasticity of tissues impacts their shape, as well as the growth and differentiation of
their cells. Nevertheless, little is known about changes in viscoelastic properties during brain …