Immune alterations in the intrauterine environment shapes offspring brain development in a sex-specific manner
Exposure to inflammation in utero or in early life is known to increase risk for
neuropsychiatric illness. The sources of inflammation can be varied, including acute …
neuropsychiatric illness. The sources of inflammation can be varied, including acute …
[HTML][HTML] Altered brain metabolites in male nonhuman primate offspring exposed to maternal immune activation
Converging data show that exposure to maternal immune activation (MIA) in utero alters
brain development in animals and increases the risk of neurodevelopmental disorders in …
brain development in animals and increases the risk of neurodevelopmental disorders in …
Excessive interstitial free-water in cortical gray matter preceding accelerated volume changes in individuals at clinical high risk for psychosis
Recent studies show that accelerated cortical gray matter (GM) volume reduction seen in
anatomical MRI can help distinguish between individuals at clinical high risk (CHR) for …
anatomical MRI can help distinguish between individuals at clinical high risk (CHR) for …
Maternal prenatal immune activation associated with brain tissue microstructure and metabolite concentrations in newborn infants
Few human studies have assessed the association of prenatal maternal immune activation
(MIA) with measures of brain development and psychiatric risk in newborn offspring. Our …
(MIA) with measures of brain development and psychiatric risk in newborn offspring. Our …
Genetic Associations Among Inflammation, White Matter Architecture, and Extracellular Free Water
Phenotypic and genetic relationships between white matter microstructure (ie, fractional
anisotropy [FA]) and peripheral inflammatory responses (ie, circulating cytokines) have …
anisotropy [FA]) and peripheral inflammatory responses (ie, circulating cytokines) have …
Elevated Extracellular Free Water in the Brain Predicts Clinical Improvement in First-Episode Psychosis
Background Despite the diverse nature of clinical trajectories after a first episode of
psychosis, few baseline characteristics have been predictive of clinical improvement, and …
psychosis, few baseline characteristics have been predictive of clinical improvement, and …
IL-6 Enhances the Activation of PI3K-AKT/mTOR-GSK-3β by Upregulating GRPR in Hippocampal Neurons of Autistic Mice
H Li, X Wang, C Hu, J Cui, H Li, X Luo… - Journal of Neuroimmune …, 2024 - Springer
Autism spectrum disorder (ASD) is a neurological disorder associated with brain
inflammation. The underlying mechanisms could be attributed to the activation of PI3K …
inflammation. The underlying mechanisms could be attributed to the activation of PI3K …
Inhibitory systems in brain evolution: pathways of vulnerability in neurodevelopmental disorders
KL Hanson, DMZ Greiner, CM Schumann… - Brain Behavior and …, 2024 - karger.com
Background: The evolution of the primate brain has been characterized by the
reorganization of key structures and circuits underlying derived specializations in sensory …
reorganization of key structures and circuits underlying derived specializations in sensory …
Altered Extracellular Matrix Structure and Elevated Stiffness in a Brain Organoid Model for Disease
MK Zur, B Bhattacharya, SB Dror, I Solomonov… - bioRxiv, 2024 - biorxiv.org
The viscoelasticity of tissues impacts their shape, as well as the growth and differentiation of
their cells. Nevertheless, little is known about changes in viscoelastic properties during brain …
their cells. Nevertheless, little is known about changes in viscoelastic properties during brain …
[PDF][PDF] Altered Extracellular Matrix Structure and Elevated Stiffness in a Brain Organoid Model for Disease
MK Zur, B Bhattacharya, SB Dror, I Solomonov… - 2024 - scholar.archive.org
The viscoelasticity of tissues impacts their shape, as well as the growth and differentiation of
their cells. Nevertheless, little is known about changes in viscoelastic properties during brain …
their cells. Nevertheless, little is known about changes in viscoelastic properties during brain …