Tissue engineering (TE) is the multi-disciplinary approach to building 3D human tissue
equivalents in the laboratory. The advancement of medical sciences and allied scientific …

Odontogenic keratocyst (OKC) and ameloblastoma (AM) are common jaw lesions with high
bone-destructive potential and recurrence rates. Recent advancements in technology led to …

The stiffness of tumors and their host tissues is much higher than most hydrogels, which are
conventionally used to study in vitro cancer progression. The tumoroid assay is an …

The biological behaviour of the cancer cell is in part controlled by its microenvironment and
in part by underlying genetics. The interaction of cancer cells with the surrounding stroma …

Stromal cells are key components of the tumour microenvironment (TME) and their
incorporation into 3D engineered tumour-stroma models is essential for tumour mimicry. By …

This article describes a case study of our journey to running more sustainable labs within the
Division of Surgery and Interventional Science at University College London (UCL), London …

Background Ameloblastoma is a locally destructive benign odontogenic tumor. While the
neoplastic cells of conventional ameloblastoma can infiltrate the connective tissue and …

Objective Engineering bone in 3D is important for both regenerative medicine purposes and
for the development of accurate in vitro models of bone tissue. The changing material …

Tumour development and progression is dependent upon tumour cell interaction with the
tissue stroma. Bioengineering the tumour-stroma microenvironment (TME) into 3D …

Cancer-associated fibroblasts (CAFs) play a major role in reorganizing the physical tumor
micro-environment and changing tissue stiffness. Herein, using an engineered three …