Inflammation‐related mechanisms in chronic kidney disease prediction, progression, and outcome

S Mihai, E Codrici, ID Popescu… - Journal of …, 2018 - Wiley Online Library
Persistent, low‐grade inflammation is now considered a hallmark feature of chronic kidney
disease (CKD), being involved in the development of all‐cause mortality of these patients …

Cardiac surgery-associated acute kidney injury: risk factors, pathophysiology and treatment

Y Wang, R Bellomo - Nature Reviews Nephrology, 2017 - nature.com
Cardiac surgery-associated acute kidney injury (CSA-AKI) is the most common clinically
important complication in adult patients undergoing open heart surgery, and is associated …

Comparative accuracy of biomarkers for the prediction of hospital-acquired acute kidney injury: a systematic review and meta-analysis

HC Pan, SY Yang, TTY Chiou, CC Shiao, CH Wu… - Critical Care, 2022 - Springer
Background Several biomarkers have been proposed to predict the occurrence of acute
kidney injury (AKI); however, their efficacy varies between different trials. The aim of this …

Biomarkers of acute and chronic kidney disease

WR Zhang, CR Parikh - Annual review of physiology, 2019 - annualreviews.org
The current unidimensional paradigm of kidney disease detection is incompatible with the
complexity and heterogeneity of renal pathology. The diagnosis of kidney disease has …

Biomarkers in acute kidney injury–pathophysiological basis and clinical performance

EV Schrezenmeier, J Barasch, K Budde… - Acta …, 2017 - Wiley Online Library
Various biomarkers of acute kidney injury (AKI) have been discovered and characterized in
the recent past. These molecules can be detected in urine or blood and signify structural …

Proficient novel biomarkers guide early detection of acute kidney injury: a review

S Jana, P Mitra, S Roy - Diseases, 2022 - mdpi.com
The definition of acute kidney injury (AKI), despite improvements in criteria, continues to be
based on the level of serum creatinine and urinary output that do not specifically indicate …

Acute kidney injury

C Ronco, R Bellomo, JA Kellum - The Lancet, 2019 - thelancet.com
Acute kidney injury (AKI) is defined by a rapid increase in serum creatinine, decrease in
urine output, or both. AKI occurs in approximately 10–15% of patients admitted to hospital …

Biomarkers of AKI: a review of mechanistic relevance and potential therapeutic implications

JL Alge, JM Arthur - Clinical journal of the American Society of …, 2015 - journals.lww.com
AKI is a common clinical condition associated with a number of adverse outcomes. More
timely diagnosis would allow for earlier intervention and could improve patient outcomes …

[HTML][HTML] Urinary, plasma, and serum biomarkers' utility for predicting acute kidney injury associated with cardiac surgery in adults: a meta-analysis

J Ho, N Tangri, P Komenda, A Kaushal, M Sood… - American journal of …, 2015 - Elsevier
Background Early accurate detection of acute kidney injury (AKI) occurring after cardiac
surgery may improve morbidity and mortality. Although several novel biomarkers have been …

A basic science view of acute kidney injury biomarkers

JR Charlton, D Portilla, MD Okusa - Nephrology Dialysis …, 2014 - academic.oup.com
Over the last decade, significant progress has been made in the identification and validation
of novel biomarkers as well as refinements in the use of serum creatinine as a marker of …