Given the functional interdependencies between the molecular components in a human cell,
a disease is rarely a consequence of an abnormality in a single gene, but reflects the …

Complex biological systems and cellular networks may underlie most genotype to
phenotype relationships. Here, we review basic concepts in network biology, discussing …

A network of disorders and disease genes linked by known disorder–gene associations
offers a platform to explore in a single graph-theoretic framework all known phenotype and …

Rapidly increasing amounts of molecular interaction data are being produced by various
experimental techniques and computational prediction methods. In order to gain insight into …

Despite considerable progress in genome-and proteome-based high-throughput screening
methods and in rational drug design, the increase in approved drugs in the past decade did …

Abstract In contrast to 5-methylcytosine (5-mC), which has been studied extensively,,, little is
known about 5-hydroxymethylcytosine (5-hmC), a recently identified epigenetic modification …

Cellular functions depend on numerous protein-coding and noncoding RNAs and the RNA-
binding proteins associated with them, which form ribonucleoprotein complexes (RNPs) …

The identification of genes associated with hereditary disorders has contributed to improving
medical care and to a better understanding of gene functions, interactions, and pathways …

Stress granules (SGs) are membraneless cell compartments formed in response to different
stress stimuli, wherein translation factors, mRNAs, RNA-binding proteins (RBPs) and other …

A key property of complex biological systems is the presence of interaction networks formed
by its different components, primarily proteins. These are crucial for all levels of cellular …