Stress granules, RNA-binding proteins and polyglutamine diseases: too much aggregation?
Stress granules (SGs) are membraneless cell compartments formed in response to different
stress stimuli, wherein translation factors, mRNAs, RNA-binding proteins (RBPs) and other …
stress stimuli, wherein translation factors, mRNAs, RNA-binding proteins (RBPs) and other …
Network medicine: a network-based approach to human disease
Given the functional interdependencies between the molecular components in a human cell,
a disease is rarely a consequence of an abnormality in a single gene, but reflects the …
a disease is rarely a consequence of an abnormality in a single gene, but reflects the …
Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders
Genetic and genomic approaches have implicated hundreds of genetic loci in
neurodevelopmental disorders and neurodegeneration, but mechanistic understanding …
neurodevelopmental disorders and neurodegeneration, but mechanistic understanding …
PP2A as a master regulator of the cell cycle
N Wlodarchak, Y **ng - Critical reviews in biochemistry and …, 2016 - Taylor & Francis
Abstract Protein phosphatase 2A (PP2A) plays a critical multi-faceted role in the regulation
of the cell cycle. It is known to dephosphorylate over 300 substrates involved in the cell …
of the cell cycle. It is known to dephosphorylate over 300 substrates involved in the cell …
Spinocerebellar ataxias: prospects and challenges for therapy development
The spinocerebellar ataxias (SCAs) comprise more than 40 autosomal dominant
neurodegenerative disorders that present principally with progressive ataxia. Within the past …
neurodegenerative disorders that present principally with progressive ataxia. Within the past …
Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review
Despite considerable progress in genome-and proteome-based high-throughput screening
methods and in rational drug design, the increase in approved drugs in the past decade did …
methods and in rational drug design, the increase in approved drugs in the past decade did …
[HTML][HTML] Interactome networks and human disease
Complex biological systems and cellular networks may underlie most genotype to
phenotype relationships. Here, we review basic concepts in network biology, discussing …
phenotype relationships. Here, we review basic concepts in network biology, discussing …
Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine
Abstract In contrast to 5-methylcytosine (5-mC), which has been studied extensively,,, little is
known about 5-hydroxymethylcytosine (5-hmC), a recently identified epigenetic modification …
known about 5-hydroxymethylcytosine (5-hmC), a recently identified epigenetic modification …
Protein interaction networks in neurodegenerative diseases: From physiological function to aggregation
The accumulation of protein inclusions is linked to many neurodegenerative diseases that
typically develop in older individuals, due to a combination of genetic and environmental …
typically develop in older individuals, due to a combination of genetic and environmental …
The human disease network
KI Goh, ME Cusick, D Valle, B Childs… - Proceedings of the …, 2007 - National Acad Sciences
A network of disorders and disease genes linked by known disorder–gene associations
offers a platform to explore in a single graph-theoretic framework all known phenotype and …
offers a platform to explore in a single graph-theoretic framework all known phenotype and …