The long and short non-coding RNAs modulating EZH2 signaling in cancer
S Mirzaei, MH Gholami, K Hushmandi… - Journal of hematology & …, 2022 - Springer
Non-coding RNAs (ncRNAs) are a large family of RNA molecules with no capability in
encoding proteins. However, they participate in developmental and biological processes …
encoding proteins. However, they participate in developmental and biological processes …
EZH1/2 as targets for cancer therapy
R An, YQ Li, YL Lin, F Xu, MM Li, Z Liu - Cancer Gene Therapy, 2023 - nature.com
The enhancer of zeste homolog 2 (EZH2) and its highly related homolog EZH1 are
considered to be epigenetic silencing factors, and they play key roles in the growth and …
considered to be epigenetic silencing factors, and they play key roles in the growth and …
LINE-1 RNA causes heterochromatin erosion and is a target for amelioration of senescent phenotypes in progeroid syndromes
Constitutive heterochromatin is responsible for genome repression of DNA enriched in
repetitive sequences, telomeres, and centromeres. During physiological and pathological …
repetitive sequences, telomeres, and centromeres. During physiological and pathological …
SARS-CoV-2 genomes from Saudi Arabia implicate nucleocapsid mutations in host response and increased viral load
Monitoring SARS-CoV-2 spread and evolution through genome sequencing is essential in
handling the COVID-19 pandemic. Here, we sequenced 892 SARS-CoV-2 genomes …
handling the COVID-19 pandemic. Here, we sequenced 892 SARS-CoV-2 genomes …
PRC2-EZH1 contributes to circadian gene expression by orchestrating chromatin states and RNA polymerase II complex stability
Circadian rhythmicity of gene expression is a conserved feature of cell physiology. This
involves fine-tuning between transcriptional and post-transcriptional mechanisms and …
involves fine-tuning between transcriptional and post-transcriptional mechanisms and …
EZH2 as a Regulator of CD8+ T Cell Fate and Function
CJ Stairiker, GD Thomas, S Salek-Ardakani - Frontiers in Immunology, 2020 - frontiersin.org
Enhancer of zeste 2 (EZH2) is the catalytic subunit of the Polycomb Repressive Complex 2
(PRC2) that mediates di-and trimethylation of histone 3 lysine 27 effectively precluding …
(PRC2) that mediates di-and trimethylation of histone 3 lysine 27 effectively precluding …
The phosphorylation to acetylation/methylation cascade in transcriptional regulation: how kinases regulate transcriptional activities of DNA/histone-modifying enzymes
P Zhao, S Malik - Cell & Bioscience, 2022 - Springer
Transcription factors directly regulate gene expression by recognizing and binding to
specific DNA sequences, involving the dynamic alterations of chromatin structure and the …
specific DNA sequences, involving the dynamic alterations of chromatin structure and the …
Saudi Arabian SARS-CoV-2 genomes implicate a mutant Nucleocapsid protein in modulating host interactions and increased viral load in COVID-19 patients
Monitoring SARS-CoV-2 spread and evolution through genome sequencing is essential in
handling the COVID-19 pandemic. The availability of patient hospital records is crucial for …
handling the COVID-19 pandemic. The availability of patient hospital records is crucial for …
Malat-1-PRC2-EZH1 interaction supports adaptive oxidative stress dependent epigenome remodeling in skeletal myotubes
PRC2-mediated epigenetic function involves the interaction with long non-coding RNAs
(lncRNAs). Although the identity of some of these RNAs has been elucidated in the context …
(lncRNAs). Although the identity of some of these RNAs has been elucidated in the context …
The E3 ligase HUWE1 inhibition as a therapeutic strategy to target MYC in multiple myeloma
LJ Crawford, DC Campbell, JJ Morgan, MA Lawson… - Oncogene, 2020 - nature.com
Proteasome inhibitors have provided a significant advance in the treatment of multiple
myeloma (MM). Consequently, there is increasing interest in develo** strategies to target …
myeloma (MM). Consequently, there is increasing interest in develo** strategies to target …