There has been a significant progress in our understanding of the molecular mechanisms by
which calcium (Ca2+) ions mediate various types of cardiac arrhythmias. A growing list of …

Hypertrophic cardiomyopathy (HCM), a relatively common disease, is diagnosed clinically
by unexplained cardiac hypertrophy and pathologically by myocyte hypertrophy, disarray …

Cardiac muscle cells are equipped with specialized biochemical machineries for the rapid
generation of force and movement central to the work generated by the heart. During each …

Cardiomyopathies are diseases of heart muscle that may result from a diverse array of
conditions that damage the heart and other organs and impair myocardial function, including …

The sarcomeric proteins represent the structural building blocks of heart muscle, which are
essential for contraction and relaxation. During recent years, it has become evident that …

Troponin is the regulatory complex of the myofibrillar thin filament that plays a critical role in
regulating excitation-contraction coupling in the heart. Troponin is composed of three distinct …

▪ Abstract Cardiomyopathies are primary disorders of cardiac muscle associated with
abnormalities of cardiac wall thickness, chamber size, contraction, relaxation, conduction …

Troponin (Tn) is the sarcomeric Ca 2+ regulator for striated (skeletal and cardiac) muscle
contraction. On binding Ca 2+ Tn transmits information via structural changes throughout the …

In human cardiomyopathy, anatomical abnormalities such as hypertrophy and fibrosis
contribute to the risk of ventricular arrhythmias and sudden death. Here we have shown that …

Troponin (Tn) is a critical regulator of muscle contraction in cardiac muscle. Mutations in Tn
subunits are associated with hypertrophic, dilated and restrictive cardiomyopathies …