Transplanting neural progenitor cells to restore connectivity after spinal cord injury

I Fischer, JN Dulin, MA Lane - Nature Reviews Neuroscience, 2020 - nature.com
Spinal cord injury remains a scientific and therapeutic challenge with great cost to
individuals and society. The goal of research in this field is to find a means of restoring lost …

Spatial and temporal activation of spinal glial cells: role of gliopathy in central neuropathic pain following spinal cord injury in rats

YS Gwak, J Kang, GC Unabia, CE Hulsebosch - Experimental neurology, 2012 - Elsevier
In the spinal cord, neuron and glial cells actively interact and contribute to neurofunction.
Surprisingly, both cell types have similar receptors, transporters and ion channels and also …

Review of transplantation of neural stem/progenitor cells for spinal cord injury

AJ Mothe, CH Tator - International Journal of Developmental Neuroscience, 2013 - Elsevier
Spinal cord injury (SCI) is a debilitating condition often resulting in paralysis, yet currently
there is no effective treatment. Stem cell transplantation is a promising therapeutic strategy …

Biomaterial-supported cell transplantation treatments for spinal cord injury: challenges and perspectives

S Liu, T Schackel, N Weidner… - Frontiers in cellular …, 2018 - frontiersin.org
Spinal cord injury (SCI), resulting in para-and tetraplegia caused by the partial or complete
disruption of descending motor and ascending sensory neurons, represents a complex …

Vascularization of self-assembled peptide scaffolds for spinal cord injury repair

KA Tran, PP Partyka, Y **, J Bouyer, I Fischer… - Acta biomaterialia, 2020 - Elsevier
The disruption of the blood-spinal cord barrier (BSCB) following spinal cord injury
contributes to inflammation and glial scarring that inhibits axon growth and diminishes the …

Comparison of mesenchymal stromal cells from human bone marrow and adipose tissue for the treatment of spinal cord injury

Z Zhou, Y Chen, H Zhang, S Min, B Yu, B He, A ** - Cytotherapy, 2013 - Elsevier
Background aims Bone marrow and subcutaneous adipose tissue are both considered
prospective sources of mesenchymal stromal cells (MSCs), which can be used in cell …

Differential effects of brain‐derived neurotrophic factor and neurotrophin‐3 on hindlimb function in paraplegic rats

VS Boyce, J Park, FH Gage… - European Journal of …, 2012 - Wiley Online Library
We compared the effect of viral administration of brain‐derived neurotrophic factor (BDNF)
or neurotrophin 3 (NT‐3) on locomotor recovery in adult rats with complete thoracic (T10) …

Therapeutic potential of astrocyte transplantation

N Hastings, WL Kuan, A Osborne… - Cell …, 2022 - journals.sagepub.com
Cell transplantation is an attractive treatment strategy for a variety of brain disorders, as it
promises to replenish lost functions and rejuvenate the brain. In particular, transplantation of …

Magnetic alignment of injectable hydrogel scaffolds for spinal cord injury repair

KA Tran, Y **, J Bouyer, BJ DeOre, Ł Suprewicz… - Biomaterials …, 2022 - pubs.rsc.org
Injectable hydrogels for cell delivery and tissue regeneration have several advantages over
pre-fabricated scaffolds that require more invasive transplantation procedures, but lack the …

Amelioration of motor/sensory dysfunction and spasticity in a rat model of acute lumbar spinal cord injury by human neural stem cell transplantation

S van Gorp, M Leerink, O Kakinohana… - Stem cell research & …, 2013 - Springer
Introduction Intraspinal grafting of human neural stem cells represents a promising approach
to promote recovery of function after spinal trauma. Such a treatment may serve to: I) provide …