Transplanting neural progenitor cells to restore connectivity after spinal cord injury
Spinal cord injury remains a scientific and therapeutic challenge with great cost to
individuals and society. The goal of research in this field is to find a means of restoring lost …
individuals and society. The goal of research in this field is to find a means of restoring lost …
Spatial and temporal activation of spinal glial cells: role of gliopathy in central neuropathic pain following spinal cord injury in rats
In the spinal cord, neuron and glial cells actively interact and contribute to neurofunction.
Surprisingly, both cell types have similar receptors, transporters and ion channels and also …
Surprisingly, both cell types have similar receptors, transporters and ion channels and also …
Review of transplantation of neural stem/progenitor cells for spinal cord injury
AJ Mothe, CH Tator - International Journal of Developmental Neuroscience, 2013 - Elsevier
Spinal cord injury (SCI) is a debilitating condition often resulting in paralysis, yet currently
there is no effective treatment. Stem cell transplantation is a promising therapeutic strategy …
there is no effective treatment. Stem cell transplantation is a promising therapeutic strategy …
Biomaterial-supported cell transplantation treatments for spinal cord injury: challenges and perspectives
S Liu, T Schackel, N Weidner… - Frontiers in cellular …, 2018 - frontiersin.org
Spinal cord injury (SCI), resulting in para-and tetraplegia caused by the partial or complete
disruption of descending motor and ascending sensory neurons, represents a complex …
disruption of descending motor and ascending sensory neurons, represents a complex …
Vascularization of self-assembled peptide scaffolds for spinal cord injury repair
The disruption of the blood-spinal cord barrier (BSCB) following spinal cord injury
contributes to inflammation and glial scarring that inhibits axon growth and diminishes the …
contributes to inflammation and glial scarring that inhibits axon growth and diminishes the …
Comparison of mesenchymal stromal cells from human bone marrow and adipose tissue for the treatment of spinal cord injury
Z Zhou, Y Chen, H Zhang, S Min, B Yu, B He, A ** - Cytotherapy, 2013 - Elsevier
Background aims Bone marrow and subcutaneous adipose tissue are both considered
prospective sources of mesenchymal stromal cells (MSCs), which can be used in cell …
prospective sources of mesenchymal stromal cells (MSCs), which can be used in cell …
Differential effects of brain‐derived neurotrophic factor and neurotrophin‐3 on hindlimb function in paraplegic rats
VS Boyce, J Park, FH Gage… - European Journal of …, 2012 - Wiley Online Library
We compared the effect of viral administration of brain‐derived neurotrophic factor (BDNF)
or neurotrophin 3 (NT‐3) on locomotor recovery in adult rats with complete thoracic (T10) …
or neurotrophin 3 (NT‐3) on locomotor recovery in adult rats with complete thoracic (T10) …
Therapeutic potential of astrocyte transplantation
N Hastings, WL Kuan, A Osborne… - Cell …, 2022 - journals.sagepub.com
Cell transplantation is an attractive treatment strategy for a variety of brain disorders, as it
promises to replenish lost functions and rejuvenate the brain. In particular, transplantation of …
promises to replenish lost functions and rejuvenate the brain. In particular, transplantation of …
Magnetic alignment of injectable hydrogel scaffolds for spinal cord injury repair
Injectable hydrogels for cell delivery and tissue regeneration have several advantages over
pre-fabricated scaffolds that require more invasive transplantation procedures, but lack the …
pre-fabricated scaffolds that require more invasive transplantation procedures, but lack the …
Amelioration of motor/sensory dysfunction and spasticity in a rat model of acute lumbar spinal cord injury by human neural stem cell transplantation
S van Gorp, M Leerink, O Kakinohana… - Stem cell research & …, 2013 - Springer
Introduction Intraspinal grafting of human neural stem cells represents a promising approach
to promote recovery of function after spinal trauma. Such a treatment may serve to: I) provide …
to promote recovery of function after spinal trauma. Such a treatment may serve to: I) provide …