Spinal cord injury (SCI) is a devastating neurological disorder that affects thousands of
individuals each year. Over the past decades an enormous progress has been made in our …

Neurotrophins are a family of proteins that regulate neuronal survival, synaptic function, and
neurotransmitter release, and elicit the plasticity and growth of axons within the adult central …

We tested the feasibility and safety of human-spinal-cord-derived neural stem cell (NSI-566)
transplantation for the treatment of chronic spinal cord injury (SCI). In this clinical trial, four …

▪ Abstract Nerve regeneration is a complex biological phenomenon. In the peripheral
nervous system, nerves can regenerate on their own if injuries are small. Larger injuries …

We have reviewed a battery of useful tests for evaluating sensorimotor function and plasticity
acutely and chronically in unilateral rat models of central nervous system injury. These tests …

Emerging evidence indicates that moderate intensity aerobic exercise is positively
correlated with cognitive function and memory. However, the exact mechanisms underlying …

Spinal cord injury (SCI) can lead to paraplegia or quadriplegia. Although there are no fully
restorative treatments for SCI, various rehabilitative, cellular and molecular therapies have …

It is self-evident that the adult mammalian brain and spinal cord do not regenerate after
injury, but recent discoveries have forced a reconsideration of this accepted principle …

Progress in the field of axonal regeneration research has been like the process of axonal
growth itself: there is steady progress toward reaching the target, but there are episodes of …

The Rho signaling pathway regulates the cytoskeleton and motility and plays an important
role in neuronal growth inhibition. Here we demonstrate that inactivation of Rho or its …