Multifunctional biomolecule nanostructures for cancer therapy

J Wang, Y Li, G Nie - Nature Reviews Materials, 2021 - nature.com
Biomolecule-based nanostructures are inherently multifunctional and harbour diverse
biological activities, which can be explored for cancer nanomedicine. The supramolecular …

Recent advancements in liposome technology

N Filipczak, J Pan, SSK Yalamarty… - Advanced drug delivery …, 2020 - Elsevier
The liposomes have continued to be well-recognized as an important nano-sized drug
delivery system with attractive properties, such a characteristic bilayer structure assembling …

Implant-derived magnesium induces local neuronal production of CGRP to improve bone-fracture healing in rats

Y Zhang, J Xu, YC Ruan, MK Yu, M O'Laughlin… - Nature medicine, 2016 - nature.com
Orthopedic implants containing biodegradable magnesium have been used for fracture
repair with considerable efficacy; however, the underlying mechanisms by which these …

Strategies for non-viral vectors targeting organs beyond the liver

J Kim, Y Eygeris, RC Ryals, A Jozić, G Sahay - Nature nanotechnology, 2024 - nature.com
In recent years, nanoparticles have evolved to a clinical modality to deliver diverse nucleic
acids. Rising interest in nanomedicines comes from proven safety and efficacy profiles …

[HTML][HTML] Exosome-guided bone targeted delivery of Antagomir-188 as an anabolic therapy for bone loss

Y Hu, X Li, Q Zhang, Z Gu, Y Luo, J Guo, X Wang… - Bioactive materials, 2021 - Elsevier
The differentiation shift from osteogenesis to adipogenesis of bone marrow mesenchymal
stem cells (BMSCs) characterizes many pathological bone loss conditions. Stromal cell …

Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation

D Li, J Liu, B Guo, C Liang, L Dang, C Lu, X He… - Nature …, 2016 - nature.com
Emerging evidence indicates that osteoclasts direct osteoblastic bone formation. MicroRNAs
(miRNAs) have a crucial role in regulating osteoclast and osteoblast function. However …

Development of biodegradable Zn-1X binary alloys with nutrient alloying elements Mg, Ca and Sr

HF Li, XH **e, YF Zheng, Y Cong, FY Zhou, KJ Qiu… - Scientific reports, 2015 - nature.com
Biodegradable metals have attracted considerable attentions in recent years. Besides the
early launched biodegradable Mg and Fe metals, Zn, an essential element with osteogenic …

[HTML][HTML] Bone-targeted bioengineered bacterial extracellular vesicles delivering siRNA to ameliorate osteoporosis

H Liu, H Zhang, S Wang, J Cui, W Weng, X Liu… - Composites Part B …, 2023 - Elsevier
Osteoporosis (OP), characterized by decreased bone mass and destruction of bone
microarchitecture, is the most common bone degenerative disease. Conventional treatments …

The development of functional non-viral vectors for gene delivery

S Patil, YG Gao, X Lin, Y Li, K Dang, Y Tian… - International journal of …, 2019 - mdpi.com
Gene therapy is manipulation in/of gene expression in specific cells/tissue to treat diseases.
This manipulation is carried out by introducing exogenous nucleic acids, such as DNA or …

Adjuvant physiochemistry and advanced nanotechnology for vaccine development

H Ren, W Jia, Y **e, M Yu, Y Chen - Chemical Society Reviews, 2023 - pubs.rsc.org
Vaccines comprising innovative adjuvants are rapidly reaching advanced translational
stages, such as the authorized nanotechnology adjuvants in mRNA vaccines against COVID …