Abstract Treatment of tuberculosis (TB) has been a therapeutic challenge because of not
only the naturally high resistance level of Mycobacterium tuberculosis to antibiotics but also …

The hallmark of Mycobacterium tuberculosis is its ability to persist for a long-term in host
granulomas, in a non-replicating and drug-tolerant state, and later awaken to cause disease …

Objectives It is not fully understood why inhibiting ATP synthesis in Mycobacterium species
leads to death in non-replicating cells. We investigated the bactericidal mode of action of the …

Tuberculosis (TB) has become a curable disease, thanks to the discovery of antibiotics.
However, it has remained one of the most difficult infections to treat. Most current TB …

Bacterial virulence relies on a delicate balance of signals interchanged between the
invading microbe and the host. This communication has been extensively perceived as a …

Toxin-antitoxin (TA) systems are prevalent in many bacterial genomes and have been
implicated in biofilm and persister cell formation, but the contribution of individual …

Toxin–antitoxin (TA) systems are highly conserved in members of the Mycobacterium
tuberculosis (Mtb) complex and have been proposed to play an important role in physiology …

The instability of messenger RNA is fundamental to the control of gene expression. In
bacteria, mRNA degradation generally follows an “all-or-none” pattern. This implies that if …

Persister cells form a multi-drug tolerant subpopulation within an isogenic culture of bacteria
that are genetically susceptible to antibiotics. Studies with different Gram negative and Gram …

The highly persistent and often lethal human pathogen, Mycobacterium tuberculosis
contains at least 88 toxin–antitoxin genes. More than half of these encode VapC PIN domain …