High-speed atomic force microscopy for nano-visualization of dynamic biomolecular processes

T Ando, T Uchihashi, T Fukuma - Progress in Surface Science, 2008 - Elsevier
The atomic force microscope (AFM) has a unique capability of allowing the high-resolution
imaging of biological samples on substratum surfaces in physiological solutions. Recent …

Functional extension of high-speed AFM for wider biological applications

T Uchihashi, H Watanabe, S Fukuda, M Shibata… - Ultramicroscopy, 2016 - Elsevier
High-speed atomic force microscopy (HS-AFM) has been established and used, which can
visualize biomolecules in dynamic action at high spatiotemporal resolution without …

Microfluidic fabrication of cell-derived nanovesicles as endogenous RNA carriers

W Jo, D Jeong, J Kim, S Cho, SC Jang, C Han… - Lab on a Chip, 2014 - pubs.rsc.org
Exosomes/microvesicles are known to shuttle biological signals between cells, possibly by
transferring biological signal components such as encapsulated RNAs and proteins, plasma …

Technical advances in high-speed atomic force microscopy

S Fukuda, T Ando - Biophysical Reviews, 2023 - Springer
It has been 30 years since the outset of develo** high-speed atomic force microscopy (HS-
AFM), and 15 years have passed since its establishment in 2008. This advanced microscopy …

Applications of high-speed atomic force microscopy to real-time visualization of dynamic biomolecular processes

T Uchihashi, S Scheuring - Biochimica et Biophysica Acta (BBA)-General …, 2018 - Elsevier
Background Many biological processes in a living cell are consequences of sequential and
hierarchical dynamic events of biological macromolecules such as molecular interactions …

A review of demodulation techniques for amplitude-modulation atomic force microscopy

MG Ruppert, DM Harcombe… - Beilstein journal of …, 2017 - beilstein-journals.org
In this review paper, traditional and novel demodulation methods applicable to amplitude-
modulation atomic force microscopy are implemented on a widely used digital processing …

A Kalman filter for amplitude estimation in high-speed dynamic mode atomic force microscopy

MG Ruppert, KS Karvinen, SL Wiggins… - … on Control Systems …, 2015 - ieeexplore.ieee.org
A fundamental challenge in dynamic mode atomic force microscopy (AFM) is the estimation
of the cantilever oscillation amplitude from the deflection signal, which might be distorted by …

A review of demodulation techniques for multifrequency atomic force microscopy

DM Harcombe, MG Ruppert… - Beilstein journal of …, 2020 - beilstein-journals.org
This article compares the performance of traditional and recently proposed demodulators for
multifrequency atomic force microscopy. The compared methods include the lock-in …

High‐speed atomic force microscopy for observing dynamic biomolecular processes

T Ando, T Uchihashi, N Kodera… - Journal of Molecular …, 2007 - Wiley Online Library
The atomic force microscope (AFM) is unique in its capability to capture high‐resolution
images of biological samples in liquids. This capability will become more valuable to …

[HTML][HTML] Architecture of zero-latency ultrafast amplitude detector for high-speed atomic force microscopy

K Umeda, C Okamoto, M Shimizu, S Watanabe… - Applied Physics …, 2021 - pubs.aip.org
The advent of high-speed atomic force microscopy has revolutionized the field of biological
science. However, there remains a myriad of phenomena that cannot be observed due to …