The central role of cytochrome P450 in xenobiotic metabolism—a brief review on a fascinating enzyme family
F Esteves, J Rueff, M Kranendonk - Journal of xenobiotics, 2021 - mdpi.com
Human Cytochrome P450 (CYP) enzymes constitute a superfamily of membrane-bound
hemoproteins that are responsible for the metabolism of a wide variety of clinically …
hemoproteins that are responsible for the metabolism of a wide variety of clinically …
A brief insight into the etiology, genetics, and immunology of polycystic ovarian syndrome (PCOS)
Polycystic ovarian syndrome (PCOS) is a prevailing endocrine and metabolic disorder
occurring in about 6–20% of females in reproductive age. Most symptoms of PCOS arise …
occurring in about 6–20% of females in reproductive age. Most symptoms of PCOS arise …
The biosynthesis of enzymatically oxidized lipids
AA Hajeyah, WJ Griffiths, Y Wang, AJ Finch… - Frontiers in …, 2020 - frontiersin.org
Enzymatically oxidized lipids are a specific group of biomolecules that function as key
signaling mediators and hormones, regulating various cellular and physiological processes …
signaling mediators and hormones, regulating various cellular and physiological processes …
Human cytochromes P450 in health and disease
There are 18 mammalian cytochrome P450 (CYP) families, which encode 57 genes in the
human genome. CYP2, CYP3 and CYP4 families contain far more genes than the other 15 …
human genome. CYP2, CYP3 and CYP4 families contain far more genes than the other 15 …
Mechanism of oxidation reactions catalyzed by cytochrome P450 enzymes
The cytochromes P450 constitute a large family of cysteinato-heme enzymes, 1-9 are
present in all forms of life (plants, bacteria, and mammals), and play a key role in the …
present in all forms of life (plants, bacteria, and mammals), and play a key role in the …
Insect CYP genes and P450 enzymes
R Feyereisen - Insect molecular biology and biochemistry, 2012 - Elsevier
Publisher Summary This chapter discusses the insect CYP genes and P450 enzymes.
Cytochrome P450, or CYP genes, constitutes one of the largest family of genes, with …
Cytochrome P450, or CYP genes, constitutes one of the largest family of genes, with …
Heme-containing oxygenases
M Sono, MP Roach, ED Coulter, JH Dawson - Chemical reviews, 1996 - ACS Publications
Dioxygen (O2) serves two essential functions in aerobic life. It is both a terminal electron
acceptor and a biosynthetic reagent. It is this latter role for dioxygen that will be the focus of …
acceptor and a biosynthetic reagent. It is this latter role for dioxygen that will be the focus of …
The cytochrome p450 homepage
DR Nelson - Human genomics, 2009 - Springer
Abstract The Cytochrome P450 Homepage is a universal resource for nomenclature and
sequence information on cytochrome P450 (CYP) genes. The site has been in continuous …
sequence information on cytochrome P450 (CYP) genes. The site has been in continuous …
Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity
FP Guengerich - Chemical research in toxicology, 2001 - ACS Publications
Cytochrome P450 (P450) enzymes catalyze a variety of reactions and convert chemicals to
potentially reactive products as well as make compounds less toxic. Most of the P450 …
potentially reactive products as well as make compounds less toxic. Most of the P450 …
Human ATP-binding cassette (ABC) transporter family
There exist four fundamentally different classes of membrane-bound transport proteins: ion
channels; transporters; aquaporins; and ATP-powered pumps. ATP-binding cassette (ABC) …
channels; transporters; aquaporins; and ATP-powered pumps. ATP-binding cassette (ABC) …