Neutrophils are the most abundant leukocytes in blood. From the circulation, they are quickly
mobilized to sites of inflammation and/or infection. At the affected tissues, neutrophils display …

Amino acid metabolism is a critical regulator of the immune response, and its modulating
becomes a promising approach in various forms of immunotherapy. Insufficient …

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells
generated during a large array of pathologic conditions ranging from cancer to obesity …

New evidence has challenged the outdated dogma that neutrophils are a homogeneous
population of short-lived cells. Although neutrophil subpopulations with distinct functions …

SARS-CoV-2 is associated with a 3.4% mortality rate in patients with severe disease. The
pathogenesis of severe cases remains unknown. We performed an in-depth prospective …

Arginine metabolism has been a key catabolic and anabolic process throughout the
evolution of the immune response. Accruing evidence indicates that arginine-catabolizing …

Pre-eclampsia is a placental disorder that affects 3–5% of all pregnancies and is a leading
cause of maternal and fetal morbidity worldwide 1, 2. With no drug available to slow disease …

Autoimmune disease results from the immune response against self-antigens, while cancer
develops when the immune system does not respond to malignant cells. Thus, for years …

Objectives The presence of proinflammatory low-density granulocytes (LDG) has been
demonstrated in autoimmune and infectious diseases. Recently, regulatory neutrophilic …

Myeloid-derived suppressor cells (MDSCs) were initially identified in humans and mice with
cancer where they profoundly suppress T cell–and NK cell–mediated antitumor immunity …