Raman spectroscopy for chemical biology research

K Dodo, K Fujita, M Sodeoka - Journal of the American Chemical …, 2022 - ACS Publications
In chemical biology research, various fluorescent probes have been developed and used to
visualize target proteins or molecules in living cells and tissues, yet there are limitations to …

Biological imaging of chemical bonds by stimulated Raman scattering microscopy

F Hu, L Shi, W Min - Nature methods, 2019 - nature.com
All molecules consist of chemical bonds, and much can be learned from map** the
spatiotemporal dynamics of these bonds. Since its invention a decade ago, stimulated …

Super-multiplex vibrational imaging

L Wei, Z Chen, L Shi, R Long, AV Anzalone, L Zhang… - Nature, 2017 - nature.com
The ability to visualize directly a large number of distinct molecular species inside cells is
increasingly essential for understanding complex systems and processes. Even though …

Small-molecule probes from bench to bedside: advancing molecular analysis of drug–target interactions toward precision medicine

S Pan, M Lee, A Serrels, VG Brunton… - Chemical Society …, 2016 - pubs.rsc.org
Optical microscopy techniques have emerged as a cornerstone of biomedical research,
capable of probing the cellular functions of a vast range of substrates, whilst being minimally …

Multicolor activatable Raman probes for simultaneous detection of plural enzyme activities

H Fujioka, J Shou, R Kojima, Y Urano… - Journal of the …, 2020 - ACS Publications
Raman probes based on alkyne or nitrile tags hold promise for highly multiplexed imaging.
However, sensing of enzyme activities with Raman probes is difficult because few …