Extracellular vesicles in cancer: cell-to-cell mediators of metastasis

A Becker, BK Thakur, JM Weiss, HS Kim, H Peinado… - Cancer cell, 2016 - cell.com
Tumor-secreted extracellular vesicles (EVs) are critical mediators of intercellular
communication between tumor cells and stromal cells in local and distant …

Tumor‐associated macrophages in liver cancer: from mechanisms to therapy

K Cheng, N Cai, J Zhu, X Yang, H Liang… - Cancer …, 2022 - Wiley Online Library
Multidimensional analyses have demonstrated the presence of a unique tumor
microenvironment (TME) in liver cancer. Tumor‐associated macrophages (TAMs) are …

Using exosomes, naturally-equipped nanocarriers, for drug delivery

EV Batrakova, MS Kim - Journal of Controlled Release, 2015 - Elsevier
Exosomes offer distinct advantages that uniquely position them as highly effective drug
carriers. Comprised of cellular membranes with multiple adhesive proteins on their surface …

Role of exosomal non-coding RNAs from tumor cells and tumor-associated macrophages in the tumor microenvironment

Z Xu, Y Chen, L Ma, Y Chen, J Liu, Y Guo, T Yu… - Molecular Therapy, 2022 - cell.com
Exosomes have a crucial role in intercellular communication and mediate interactions
between tumor cells and tumor-associated macrophages (TAMs). Exosome-encapsulated …

Biomedical polymers: synthesis, properties, and applications

WH Chen, QW Chen, Q Chen, C Cui, S Duan… - Science China …, 2022 - Springer
Biomedical polymers have been extensively developed for promising applications in a lot of
biomedical fields, such as therapeutic medicine delivery, disease detection and diagnosis …

Engineered extracellular vesicles and their mimetics for cancer immunotherapy

C Liu, Y Wang, L Li, D He, J Chi, Q Li, Y Wu… - Journal of Controlled …, 2022 - Elsevier
Extracellular vesicles (EVs) are heterogeneous membranous vesicles secreted by living
cells that are involved in many physiological and pathological processes as intermediaries …

Circulating microRNAs in cancer: potential and challenge

M Cui, H Wang, X Yao, D Zhang, Y **e, R Cui… - Frontiers in …, 2019 - frontiersin.org
MicroRNAs (miRNAs) are endogenous non-coding small RNA molecules that can be
secreted into the circulation and exist in remarkably stable forms. Like intercellular miRNAs …

Exosome-delivered EGFR regulates liver microenvironment to promote gastric cancer liver metastasis

H Zhang, T Deng, R Liu, M Bai, L Zhou, X Wang… - Nature …, 2017 - nature.com
The metastatic organotropism has been one of the cancer's greatest mysteries since the
'seed and soil'hypothesis. Although the role of EGFR in cancer cells is well studied, the …

Exosomes released from tumor-associated macrophages transfer miRNAs that induce a Treg/Th17 cell imbalance in epithelial ovarian cancer

J Zhou, X Li, X Wu, T Zhang, Q Zhu, X Wang… - Cancer immunology …, 2018 - AACR
The immune microenvironment is crucial for epithelial ovarian cancer (EOC) progression
and consists of tumor-associated macrophages (TAM) and T lymphocytes, such as …

Human umbilical cord mesenchymal stem cell exosomes enhance angiogenesis through the Wnt4/β-catenin pathway

B Zhang, X Wu, X Zhang, Y Sun, Y Yan… - Stem cells …, 2015 - academic.oup.com
Human umbilical cord mesenchymal stem cells (hucMSCs) and their exosomes have been
considered as potential therapeutic tools for tissue regeneration; however, the underlying …