Deficiency in cerebral amyloid β-protein (Aβ) clearance is implicated in the pathogenesis of
the common late-onset forms of Alzheimer's disease (AD). Accumulation of misfolded Aβ in …

The phagocytic response of innate immune cells such as macrophages is defined by the
activation of complex signaling networks that are stimulated by microbial contact. Many …

Scavenger receptors constitute a large family of proteins that are structurally diverse and
participate in a wide range of biological functions. These receptors are expressed …

Macrophage type-I and type-II class-A scavenger receptors (MSR-A) are implicated in the
pathological deposition of cholesterol during atherogenesis as a result of receptor-mediated …

Bacterial sepsis and septic shock result from the overproduction of inflammatory mediators
as a consequence of the interaction of the immune system with bacteria and bacterial wall …

Oxidative modification of LDL is known to elicit an array of pro-atherogenic responses, but it
is generally underappreciated that oxidized LDL (OxLDL) exists in multiple forms …

It is now possible to grow DC-like cells in culture17-21 and extensive cell membrane
processes that are acquired late the first monoclonal antibodies (MoAbs) 22, 23 that react …

A null mutation in the scavenger receptor gene CD36 was created in mice by targeted
homologous recombination. These mice produced no detectable CD36 protein, were viable …

Amyloid β (Aβ) plays a pivotal role in the progression of Alzheimer's disease (AD) through its
neurotoxic and inflammatory effects. On one hand, Aβ binds to microglia and activates them …

Liver sinusoidal endothelial cells (LSECs) are the most abundant non-parenchymal cells
lining the sinusoidal capillaries of the hepatic system. LSECs are characterized with …