Introduction Under specific conditions, a weak lead stimulus, or “prepulse”, can inhibit the
startling effects of a subsequent intense abrupt stimulus. This startle-inhibiting effect of the …

Cognitive deficits in schizophrenia are among the core symptoms of the disease, correlate
with functional outcome, and are not well treated with current antipsychotic therapies. In …

Although research on the reasons for engaging in nonsuicidal self-injury (NSSI) has
increased dramatically in the last few years, there are still many aspects of this pernicious …

Mutant mouse models related to schizophrenia have been based primarily on the
pathophysiology of schizophrenia, the known effects of antipsychotic drugs, and candidate …

Translational control depends on phosphorylation of eIF2α by PKR-like ER kinase (PERK).
To examine the role of PERK in cognitive function, we selectively disrupted PERK …

Several lines of evidence suggest that cholinergic deficits may contribute to the
pathophysiology of psychiatric disorders as well as Alzheimer's disease. There is growing …

Sensorimotor gating, or the ability of a sensory event to suppress a motor response, can be
measured operationally via prepulse inhibition (PPI) of the startle response. PPI is deficient …

Recent evidence suggests that prepulse inhibition (PPI) levels relate to executive function
possibly by a prefrontal cortex (PFC) dopamine (DA) link. We explored the effects of …

Although the requirement for new protein synthesis in synaptic plasticity and memory has
been well established, recent genetic, molecular, electrophysiological, and pharmacological …

Patients with chronic psychotic disorders (CPD) exhibit deficient sensorimotor gating
(measured by prepulse inhibition (PPI) of startle) and mismatch negativity (MMN). In healthy …