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Spatial architecture of the immune microenvironment orchestrates tumor immunity and therapeutic response
T Fu, LJ Dai, SY Wu, Y ** of the tumor and peripheral blood immune landscape in human pancreatic cancer
NG Steele, ES Carpenter, SB Kemp, VR Sirihorachai… - Nature cancer, 2020 - nature.com
Pancreatic ductal adenocarcinoma (PDA) is characterized by an immune-suppressive tumor
microenvironment that renders it largely refractory to immunotherapy. We implemented a …
microenvironment that renders it largely refractory to immunotherapy. We implemented a …
Regulatory T-cell depletion alters the tumor microenvironment and accelerates pancreatic carcinogenesis
Y Zhang, J Lazarus, NG Steele, W Yan, HJ Lee… - Cancer …, 2020 - aacrjournals.org
Regulatory T cells (Treg) are abundant in human and mouse pancreatic cancer. To
understand the contribution to the immunosuppressive microenvironment, we depleted …
understand the contribution to the immunosuppressive microenvironment, we depleted …
[HTML][HTML] Macrophage-released pyrimidines inhibit gemcitabine therapy in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDA) is characterized by abundant infiltration of tumor-
associated macrophages (TAMs). TAMs have been reported to drive resistance to …
associated macrophages (TAMs). TAMs have been reported to drive resistance to …
Single-cell and spatial transcriptome analyses reveal tertiary lymphoid structures linked to tumour progression and immunotherapy response in nasopharyngeal …
Tertiary lymphoid structures are immune cell aggregates linked with cancer outcomes, but
their interactions with tumour cell aggregates are unclear. Using nasopharyngeal carcinoma …
their interactions with tumour cell aggregates are unclear. Using nasopharyngeal carcinoma …
Immunotherapy efficacy on mismatch repair-deficient colorectal cancer: From bench to bedside
Colorectal cancers (CRCs) with deficient mismatch repair (dMMR) or microsatellite instability-
high (MSI-H) often have sustained responses to immune checkpoint inhibitors (ICIs) …
high (MSI-H) often have sustained responses to immune checkpoint inhibitors (ICIs) …
[HTML][HTML] Molecular cartography uncovers evolutionary and microenvironmental dynamics in sporadic colorectal tumors
Colorectal cancer exhibits dynamic cellular and genetic heterogeneity during progression
from precursor lesions toward malignancy. Analysis of spatial multi-omic data from 31 …
from precursor lesions toward malignancy. Analysis of spatial multi-omic data from 31 …
Inhibition of ATM increases interferon signaling and sensitizes pancreatic cancer to immune checkpoint blockade therapy
Combinatorial strategies are needed to overcome the resistance of pancreatic cancer to
immune checkpoint blockade (ICB). DNA damage activates the innate immune response …
immune checkpoint blockade (ICB). DNA damage activates the innate immune response …
Hydrogen sulfide creates a favorable immune microenvironment for colon cancer
T Yue, J Li, J Zhu, S Zuo, X Wang, Y Liu, J Liu… - Cancer …, 2023 - aacrjournals.org
Immunotherapy can elicit robust anticancer responses in the clinic. However, a large
proportion of patients with colorectal cancer do not benefit from treatment. Although previous …
proportion of patients with colorectal cancer do not benefit from treatment. Although previous …