Naturally occurring modified ribonucleosides
PJ McCown, A Ruszkowska, CN Kunkler… - Wiley …, 2020 - Wiley Online Library
The chemical identity of RNA molecules beyond the four standard ribonucleosides has
fascinated scientists since pseudouridine was characterized as the “fifth” ribonucleotide in …
fascinated scientists since pseudouridine was characterized as the “fifth” ribonucleotide in …
The processing, gene regulation, biological functions, and clinical relevance of N4-acetylcytidine on RNA: a systematic review
N4-acetylcytidine (ac4C) is often considered to be a conservative, chemically modified
nucleoside present on tRNA and rRNA. Recent studies have shown extensive ac4C …
nucleoside present on tRNA and rRNA. Recent studies have shown extensive ac4C …
[HTML][HTML] Acetylation of cytidine in mRNA promotes translation efficiency
Generation of the" epitranscriptome" through post-transcriptional ribonucleoside
modification embeds a layer of regulatory complexity into RNA structure and function. Here …
modification embeds a layer of regulatory complexity into RNA structure and function. Here …
Direct epitranscriptomic regulation of mammalian translation initiation through N4-acetylcytidine
Summary mRNA function is influenced by modifications that modulate canonical nucleobase
behavior. We show that a single modification mediates distinct impacts on mRNA translation …
behavior. We show that a single modification mediates distinct impacts on mRNA translation …
Dynamic RNA acetylation revealed by quantitative cross-evolutionary map**
Abstract N 4-acetylcytidine (ac4C) is an ancient and highly conserved RNA modification that
is present on tRNA and rRNA and has recently been investigated in eukaryotic mRNA …
is present on tRNA and rRNA and has recently been investigated in eukaryotic mRNA …
Transfer RNA modifications and cellular thermotolerance
T Ohira, T Suzuki - Molecular Cell, 2024 - cell.com
RNA molecules are modified post-transcriptionally to acquire their diverse functions.
Transfer RNA (tRNA) has the widest variety and largest numbers of RNA modifications …
Transfer RNA (tRNA) has the widest variety and largest numbers of RNA modifications …
Site-Specific Synthesis of N4-Acetylcytidine in RNA Reveals Physiological Duplex Stabilization
N 4-Acetylcytidine (ac4C) is a post-transcriptional modification of RNA that is conserved
across all domains of life. All characterized sites of ac4C in eukaryotic RNA occur in the …
across all domains of life. All characterized sites of ac4C in eukaryotic RNA occur in the …
Conformational rigidity of specific pyrimidine residues in tRNA arises from posttranscriptional modifications that enhance steric interaction between the base and the 2' …
G Kawai, Y Yamamoto, T Kamimura, T Masegi… - Biochemistry, 1992 - ACS Publications
Department of Biophysics and Biochemistry, Faculty of Science, University of Tokyo, Hongo,
Bunkyo-ku, Tokyo 113, Japan, Department of Life Chemistry, Tokyo Institute of Technology …
Bunkyo-ku, Tokyo 113, Japan, Department of Life Chemistry, Tokyo Institute of Technology …
The yeast rapid tRNA decay pathway primarily monitors the structural integrity of the acceptor and T-stems of mature tRNA
JM Whipple, EA Lane, I Chernyakov… - Genes & …, 2011 - genesdev.cshlp.org
tRNAs, like other RNAs, are subject to quality control steps during and after biosynthesis. We
previously described a rapid tRNA degradation (RTD) pathway in which the 5′–3 …
previously described a rapid tRNA degradation (RTD) pathway in which the 5′–3 …
Targeting N4‐acetylcytidine suppresses hepatocellular carcinoma progression by repressing eEF2‐mediated HMGB2 mRNA translation
H Liu, L Xu, S Yue, H Su, X Chen, Q Liu… - Cancer …, 2024 - Wiley Online Library
Abstract Background N4‐acetylcytidine (ac4C) represents a novel messenger RNA (mRNA)
modification, and its associated acetyltransferase N‐acetyltransferase 10 (NAT10) plays a …
modification, and its associated acetyltransferase N‐acetyltransferase 10 (NAT10) plays a …