Most animal cell types possess the capacity to move over or through a substrate, and cell
locomotion plays a key role in both normal physiology and disease. Certain cell types are …

Nerve cells establish their connections by extending neuritic processes away from the rather
fixed position of the cell body. In the case of axons, this growth can be extensive and the …

Completion of cell division during cytokinesis requires temporally and spatially regulated
communication from the microtubule cytoskeleton to the actin cytoskeleton and the cell …

Myosins constitute a large superfamily of actin-dependent molecular motors. Phylogenetic
analysis currently places myosins into 15 classes. The conventional myosins which form …

THE genomes of all eukaryotes contain tracts of DNA in which a single base or a small
number of bases is repeated. Expansions of such tracts have been associated with several …

Dictyostelia are soil amoebae capable of extraordinary feats of survival, motility, chemotaxis,
and development. Characterised by their ability to transform from a single-celled organism …

Molecular biologists are increasingly faced with the problem of assigning a function to genes
that have been cloned. A new approach to this problem involves the manipulation of the …

The dynamic behaviour of actin filaments has been directly observed in living, motile cells
using fluorescence photoactivation. In goldfish epithelial keratocytes, the actin …

The anti-tumor effects of chemotherapy and radiation are thought to be mediated by
triggering G1/S or G2/M cell cycle checkpoints, while spindle poisons, such as paclitaxel …

After anaphase onset, animal cells build an actomyosin contractile ring that constricts the
plasma membrane to generate two daughter cells connected by a cytoplasmic bridge. The …