Immune and glial cells play a pivotal role in chronic pain. Therefore, it is possible that the
pharmacological modulation of neurotransmission from an exclusively neuronal perspective …

Purpose This is a comprehensive review of the current literature on central neuropathic pain
mechanisms that is secondary to spinal cord injury. It reviews recent and seminal findings on …

The σ1 receptor is a poorly understood membrane protein expressed throughout the human
body. Ligands targeting the σ1 receptor are in clinical trials for treatment of Alzheimer's …

Neuron-immune interaction in the dorsal root ganglia (DRG) plays a pivotal role in the
neuropathic pain development after nerve injury. Sigma-1 receptor (Sig-1R) is expressed by …

Nociplastic pain arises from altered nociception despite no clear evidence of tissue or
somatosensory system damage, and fibromyalgia syndrome can be highlighted as a …

Abstract Sigma-1 receptor (Sig-1R) is a protein present in several organs such as brain,
lung, and heart. In a cell, Sig-1R is mainly located across the membranes of the …

Over the last decade, sigma-1 receptor (Sig1R) has been recognized as a valid target for the
treatment of seizure disorders and seizure-related comorbidities. Clinical trials with Sig1R …

Opioid analgesics are highly effective painkillers for the treatment of moderate or severe
pain, but they are associated with a number of undesirable adverse effects, including the …

Sigma-1 (σ1) receptor antagonists are promising tools for neuropathic pain treatment, but it
is unknown whether σ1 receptor inhibition ameliorates the neuropathic signs induced by …

The design and synthesis of a series of piperidine and piperazine-based derivatives as
selective sigma receptor (SR) ligands associated with analgesic activity, are the focus of this …