Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases
The mitogen-activated protein kinases (MAPKs) regulate diverse cellular programs by
relaying extracellular signals to intracellular responses. In mammals, there are more than a …
relaying extracellular signals to intracellular responses. In mammals, there are more than a …
ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions
Conserved signaling pathways that activate the mitogen-activated protein kinases (MAPKs)
are involved in relaying extracellular stimulations to intracellular responses. The MAPKs …
are involved in relaying extracellular stimulations to intracellular responses. The MAPKs …
[HTML][HTML] SARS-CoV-2 replication in airway epithelia requires motile cilia and microvillar reprogramming
How SARS-CoV-2 penetrates the airway barrier of mucus and periciliary mucins to infect
nasal epithelium remains unclear. Using primary nasal epithelial organoid cultures, we …
nasal epithelium remains unclear. Using primary nasal epithelial organoid cultures, we …
[HTML][HTML] p38 MAP-kinases pathway regulation, function and role in human diseases
Mammalian p38 mitogen-activated protein kinases (MAPKs) are activated by a wide range
of cellular stresses as well as in response to inflammatory cytokines. There are four …
of cellular stresses as well as in response to inflammatory cytokines. There are four …
Targeting heat shock proteins in cancer: a promising therapeutic approach
Heat shock proteins (HSPs) are a large family of chaperones that are involved in protein
folding and maturation of a variety of “client” proteins protecting them from degradation …
folding and maturation of a variety of “client” proteins protecting them from degradation …
HSPB1 as a novel regulator of ferroptotic cancer cell death
X Sun, Z Ou, M **e, R Kang, Y Fan, X Niu, H Wang… - Oncogene, 2015 - nature.com
Ferroptosis is an iron-dependent form of non-apoptotic cell death, but its molecular
mechanism remains largely unknown. Here, we demonstrate that heat shock protein beta-1 …
mechanism remains largely unknown. Here, we demonstrate that heat shock protein beta-1 …
Preconditioning the myocardium: from cellular physiology to clinical cardiology
Yellon, Derek M., and James M. Downey. Preconditioning the Myocardium: From Cellular
Physiology to Clinical Cardiology. Physiol Rev 83: 1113-1151, 2003; 10.1152/physrev …
Physiology to Clinical Cardiology. Physiol Rev 83: 1113-1151, 2003; 10.1152/physrev …
Hydrogen sulfide is an endogenous stimulator of angiogenesis
The goal of the current study was to investigate the role of exogenous and endogenous
hydrogen sulfide (H2S) on neovascularization and wound healing in vitro and in vivo …
hydrogen sulfide (H2S) on neovascularization and wound healing in vitro and in vivo …
Oxidant stress and endothelial cell dysfunction
H Lum, KA Roebuck - American Journal of Physiology-Cell …, 2001 - journals.physiology.org
Reactive oxygen species (ROS) are generated at sites of inflammation and injury, and at low
levels, ROS can function as signaling molecules participating as signaling intermediates in …
levels, ROS can function as signaling molecules participating as signaling intermediates in …
p38 MAP kinase activation by vascular endothelial growth factor mediates actin reorganization and cell migration in human endothelial cells
Vascular endothelial growth factor (VEGF) is a potent chemotactic agent for endothelial
cells. Yet the signalling pathways that modulate the motogenic effects of VEGF in vascular …
cells. Yet the signalling pathways that modulate the motogenic effects of VEGF in vascular …