Glycoproteomics

I Bagdonaite, SA Malaker, DA Polasky… - Nature Reviews …, 2022 - nature.com
Protein glycosylation involves the co-translational or post-translational addition of glycans to
proteins and is a crucial protein modification in health and disease. The aim of …

Mass spectrometry approaches to glycomic and glycoproteomic analyses

LR Ruhaak, G Xu, Q Li, E Goonatilleke… - Chemical …, 2018 - ACS Publications
Glycomic and glycoproteomic analyses involve the characterization of oligosaccharides
(glycans) conjugated to proteins. Glycans are produced through a complicated nontemplate …

[HTML][HTML] A pragmatic guide to enrichment strategies for mass spectrometry–based glycoproteomics

NM Riley, CR Bertozzi, SJ Pitteri - Molecular & Cellular Proteomics, 2021 - Elsevier
Glycosylation is a prevalent, yet heterogeneous modification with a broad range of
implications in molecular biology. This heterogeneity precludes enrichment strategies that …

The Cosmc connection to the Tn antigen in cancer

T Ju, RP Aryal, MR Kudelka, Y Wang… - Cancer …, 2014 - content.iospress.com
The Tn antigen is a tumor-associated carbohydrate antigen that is not normally expressed in
peripheral tissues or blood cells. Expression of this antigen, which is found in a majority of …

Current strategies and findings in clinically relevant post-translational modification-specific proteomics

O Pagel, S Loroch, A Sickmann… - Expert review of …, 2015 - Taylor & Francis
Mass spectrometry-based proteomics has considerably extended our knowledge about the
occurrence and dynamics of protein post-translational modifications (PTMs). So far …

Glycopeptide enrichment and separation for protein glycosylation analysis

S Ongay, A Boichenko, N Govorukhina… - Journal of separation …, 2012 - Wiley Online Library
Protein glycosylation plays key roles in many biological processes. In addition, alterations in
protein glycosylation have been related to different diseases, as well as may affect the …

Recent advances in peptide separation by multidimensional liquid chromatography for proteome analysis

S Di Palma, ML Hennrich, AJR Heck, S Mohammed - Journal of proteomics, 2012 - Elsevier
Shotgun proteomics dominates the field of proteomics. The foundations of the strategy
consist of multiple rounds of peptide separation where chromatography provides the …