Genome mining for new enzyme chemistry

DT Nguyen, DA Mitchell, WA van der Donk - ACS catalysis, 2024 - ACS Publications
A revolution in the field of biocatalysis has enabled scalable access to compounds of high
societal values using enzymes. The construction of biocatalytic routes relies on the reservoir …

Database resources of the national center for biotechnology information

EW Sayers, J Beck, EE Bolton, JR Brister… - Nucleic Acids …, 2023 - pmc.ncbi.nlm.nih.gov
Abstract The National Center for Biotechnology Information (NCBI) provides online
information resources for biology, including the GenBank® nucleic acid sequence database …

KEGG: biological systems database as a model of the real world

M Kanehisa, M Furumichi, Y Sato… - Nucleic Acids …, 2025 - academic.oup.com
Abstract KEGG (https://www. kegg. jp/) is a database resource for representation and
analysis of biological systems. Pathway maps are the primary dataset in KEGG representing …

InterPro: the protein sequence classification resource in 2025<? mode longmeta?>

M Blum, A Andreeva, LC Florentino… - Nucleic Acids …, 2025 - academic.oup.com
Abstract InterPro (https://www. ebi. ac. uk/interpro) is a freely accessible resource for the
classification of protein sequences into families. It integrates predictive models, known as …

NCBI RefSeq: reference sequence standards through 25 years of curation and annotation

T Goldfarb, VK Kodali, S Pujar, V Brover… - Nucleic Acids …, 2025 - academic.oup.com
Reference sequences and annotations serve as the foundation for many lines of research
today, from organism and sequence identification to providing a core description of the …

How to overcome constraints imposed by microsporidian genome features to ensure gene prediction?

E Peyretaillade, RF Akossi, J Tournayre… - Journal of Eukaryotic …, 2024 - Wiley Online Library
Since the advent of sequencing techniques and due to their continuous evolution, it has
become easier and less expensive to obtain the complete genome sequence of any …

[HTML][HTML] VOGDB—database of virus orthologous groups

L Trgovec-Greif, HJ Hellinger, J Mainguy, A Pfundner… - Viruses, 2024 - mdpi.com
Computational models of homologous protein groups are essential in sequence
bioinformatics. Due to the diversity and rapid evolution of viruses, the grou** of protein …

The extent and characteristics of DNA transfer between plasmids and chromosomes

AS Kadibalban, G Landan, T Dagan - Current Biology, 2024 - cell.com
Plasmids are extrachromosomal genetic elements that reside in prokaryotes. The acquisition
of plasmids encoding beneficial traits can facilitate short-term survival in harsh …

A meta-analysis of the gut microbiome in inflammatory bowel disease patients identifies disease-associated small molecules

MM Elmassry, K Sugihara, P Chankhamjon, Y Kim… - Cell Host & Microbe, 2025 - cell.com
Gut microbiome changes have been associated with several human diseases, but the
molecular and functional details underlying these associations remain largely unknown …

Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2025

Nucleic Acids Research, 2025 - academic.oup.com
Abstract The National Genomics Data Center (NGDC), which is a part of the China National
Center for Bioinformation (CNCB), offers a comprehensive suite of database resources to …