Immune and glial cells play a pivotal role in chronic pain. Therefore, it is possible that the
pharmacological modulation of neurotransmission from an exclusively neuronal perspective …

Abstract The sigma-1 receptor (Sig-1R) is encoded by the SIGMAR1 gene and is a
nonopioid transmembrane receptor located in the mitochondrial-associated endoplasmic …

Develo** drugs for the central nervous system (CNS) requires fine chemical modifications,
as a strict balance between size and lipophilicity is necessary to improve the permeability …

Neuron-immune interaction in the dorsal root ganglia (DRG) plays a pivotal role in the
neuropathic pain development after nerve injury. Sigma-1 receptor (Sig-1R) is expressed by …

Nociplastic pain arises from altered nociception despite no clear evidence of tissue or
somatosensory system damage, and fibromyalgia syndrome can be highlighted as a …

Neuropathic pain (NP) is a frequent condition caused by a lesion in, or disease of, the
central or peripheral somatosensory nervous system and is associated with excessive …

Opioid analgesics are highly effective painkillers for the treatment of moderate or severe
pain, but they are associated with a number of undesirable adverse effects, including the …

The design and synthesis of a series of piperidine and piperazine-based derivatives as
selective sigma receptor (SR) ligands associated with analgesic activity, are the focus of this …

Spinal cord injury (SCI) is globally considered as one of the most debilitating disorders,
which interferes with daily activities and life of the affected patients. Despite many …

Repetitive transcranial magnetic stimulation (rTMS) could effectively relieve the pain and
depression in neuropathic pain (NP) patients. However, the specific treatment parameters …