Next-generation TB vaccines: progress, challenges, and prospects

L Zhuang, Z Ye, L Li, L Yang, W Gong - Vaccines, 2023 - mdpi.com
Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), is a prevalent global
infectious disease and a leading cause of mortality worldwide. Currently, the only available …

Mycobacterium smegmatis: the vanguard of mycobacterial research

IL Sparks, KM Derbyshire, WR Jacobs Jr… - Journal of …, 2023 - Am Soc Microbiol
The genus Mycobacterium contains several slow-growing human pathogens, including
Mycobacterium tuberculosis, Mycobacterium leprae, and Mycobacterium avium …

Tackling Drug-Resistant Tuberculosis: New Challenges from the Old Pathogen Mycobacterium tuberculosis

G Mancuso, A Midiri, S De Gaetano, E Ponzo… - Microorganisms, 2023 - mdpi.com
Antibiotics have played a crucial role in the reduction in the incidence of TB globally as
evidenced by the fact that before the mid-20th century, the mortality rate within five years of …

SPRINT: a Cas13a-based platform for detection of small molecules

RS Iwasaki, RT Batey - Nucleic Acids Research, 2020 - academic.oup.com
Recent efforts in biological engineering have made detection of nucleic acids in samples
more rapid, inexpensive and sensitive using CRISPR-based approaches. We expand one of …

Tuberculosis caused by Mycobacterium africanum: Knowns and unknowns

ML Silva, B Cá, NS Osório, PNS Rodrigues… - PLoS …, 2022 - journals.plos.org
Tuberculosis (TB), one of the deadliest threats to human health, is mainly caused by 2 highly
related and human-adapted bacteria broadly known as Mycobacterium tuberculosis and …

[HTML][HTML] New estimation of the prevalence of chronic pulmonary aspergillosis (CPA) related to pulmonary TB–a revised burden for India

DW Denning, DC Cole, A Ray - IJID regions, 2023 - Elsevier
Background Chronic pulmonary aspergillosis (CPA) may be confused with, or a coinfection
of, pulmonary tuberculosis (PTB), or may manifest itself after completion of antituberculous …

Formulation strategies for bacteriophages to target intracellular bacterial pathogens

W Yan, P Banerjee, M Xu, S Mukhopadhyay… - Advanced Drug Delivery …, 2021 - Elsevier
Bacteriophages (Phages) are antibacterial viruses that are unaffected by antibiotic drug
resistance. Many Phase I and Phase II phage therapy clinical trials have shown acceptable …

A heterogeneous ensemble forecasting model for disease prediction

N Sharma, J Dev, M Mangla, VM Wadhwa… - New Generation …, 2021 - Springer
The manuscript presents a bragging-based ensemble forecasting model for predicting the
number of incidences of a disease based on past occurrences. The objectives of this …

Caloric restriction promotes immunometabolic reprogramming leading to protection from tuberculosis

C Palma, C La Rocca, V Gigantino, G Aquino… - Cell metabolism, 2021 - cell.com
There is a strong relationship between metabolic state and susceptibility to Mycobacterium
tuberculosis (MTB) infection, with energy metabolism setting the basis for an exaggerated …

Lipoarabinomannan as a point-of-care assay for diagnosis of tuberculosis: how far are we to use it?

J Flores, JC Cancino, L Chavez-Galan - Frontiers in microbiology, 2021 - frontiersin.org
Tuberculosis (TB) is still a severe public health problem; the current diagnostic tests have
limitations that delay treatment onset. Lipoarabinomannan (LAM) is a glycolipid that is a …