Introduction Although antimicrobials have traditionally been used to treat infections and
improve health outcomes, resistance to commonly used antimicrobials has posed a major …

Sepsis, a dysregulated immune response due to life-threatening organ dysfunction, caused
by drug-resistant pathogens, is a major global health threat contributing to high disease …

Background There is limited data on antibiotic treatment in hospitalized neonates in low-and
middle-income countries (LMICs). We aimed to describe patterns of antibiotic use …

Neonatal sepsis is defined as a systemic infection within the first 28 days of life, with early-
onset sepsis (EOS) occurring within the first 72h, although the definition of EOS varies in …

Infections remain a leading cause of death in neonates. The sparse antibiotic development
pipeline and challenges in conducting neonatal research have resulted in few effective …

Background High levels of antimicrobial resistance (AMR) are propagating deaths due to
neonatal and paediatric infections globally. This is of particular concern in Southeast Asia …

Bacterial infections are a major cause of mortality in preterm babies, yet our understanding
of early-life disease-associated immune dysregulation remains limited. Here, we combine …

Neonatal sepsis causes significant global morbidity and mortality, with the highest burden in
resource-limited settings where 99% of neonatal deaths occur. There are multiple …

Background Antimicrobial resistance (AMR) has emerged as a global threat to healthcare
resulting in an increase in morbidity and mortality. Neonatal sepsis is ranked as the third …

Sepsis remains a significant cause of neonatal morbidity and mortality in China. A better
understanding of neonatal sepsis in China as compared with other industrialized and non …