Safety challenges and application strategies for the use of dendrimers in medicine

X Li, A Naeem, S **ao, L Hu, J Zhang, Q Zheng - Pharmaceutics, 2022 - mdpi.com
Dendrimers are used for a variety of applications in medicine but, due to their host–guest
and entrapment characteristics, are particularly used for the delivery of genes and drugs …

Versatile delivery systems for non-platinum metal-based anticancer therapeutic agents

Y Gou, GJ Huang, J Li, F Yang, H Liang - Coordination chemistry reviews, 2021 - Elsevier
Platinum-based anticancer drugs currently available in the market are associated with
severe side effects. Therefore, extensive research has been performed to design and …

[HTML][HTML] Lipid-coated ruthenium dendrimer conjugated with doxorubicin in anti-cancer drug delivery: Introducing protocols

S Michlewska, Z Garaiova, V Šubjakova… - Colloids and Surfaces B …, 2023 - Elsevier
One of the major limitations for the treatment of many diseases is an inability of drugs to
cross the cell membrane barrier. Different kinds of carriers are being investigated to improve …

Carbosilane ruthenium metallodendrimer as alternative anti-cancer drug carrier in triple negative breast cancer mouse model: A preliminary study

S Michlewska, M Maly, D Wojkowska… - International Journal of …, 2023 - Elsevier
Abstract The carbosilane metallodendrimer G 1-[[NCPh (oN) Ru (η6-p-cymene) Cl] Cl] 4
(CRD13), based on an arene Ru (II) complex coordinated to imino-pyridine surface groups …

[HTML][HTML] Ruthenium metallodendrimer against triple-negative breast cancer in mice

S Michlewska, D Wójkowska, C Watala, E Skiba… - … , Biology and Medicine, 2023 - Elsevier
Carbosilane metallodendrimers, based on the arene Ru (II) complex (CRD13) and
integrated to imino-pyridine surface groups have been investigated as an anticancer agent …

Combination of Copper Metallodendrimers with Conventional Antitumor Drugs to Combat Cancer in In Vitro Models

M Hołota, S Michlewska, S Garcia-Gallego… - International Journal of …, 2023 - mdpi.com
Copper carbosilane metallodendrimers containing chloride ligands and nitrate ligands were
mixed with commercially available conventional anticancer drugs, doxorubicin, methotrexate …

Unmodified and tyrosine-modified polyethylenimines as potential carriers for siRNA: Biophysical characterization and toxicity

M Kubczak, S Michlewska, M Karimov, A Ewe… - International Journal of …, 2022 - Elsevier
Polyethylenimines (PEIs) are being explored as efficient non-viral nanocarriers for nucleic
acid delivery in vitro and in vivo. To address limitations regarding PEI efficacy and …

[HTML][HTML] Heterofunctionalized polyphenolic dendrimers decorated with caffeic acid: Synthesis, characterization and antioxidant activity

M Grodzicka, CE Pena-Gonzalez, P Ortega… - Sustainable Materials …, 2022 - Elsevier
Dendrimers, branched polymer structures, have been widely studied as efficient drug
carriers. Scientists are trying to find new dendrimer-based formulations with the properties …

Metallodendrimers as a promising tool in the biomedical field: An overview

NS del Olmo, R Carloni, P Ortega… - Advances in …, 2020 - Elsevier
Metallodendrimers have emerged in recent years as promising strategies in biomedicine.
These molecules of nanometric size have attracted widespread attention, combining, in a …

Disturbance of cellular homeostasis as a molecular risk evaluation of human endothelial cells exposed to nanoparticles

P Wigner, K Zielinski, S Michlewska, P Danielska… - Scientific Reports, 2021 - nature.com
Even though application of nanoparticles in medicine seems to provide unique solutions for
drug delivery and diagnosis diseases, understanding interactions between nanoscale …