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Multiscale simulations of biological membranes: the challenge to understand biological phenomena in a living substance
Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …
composition and structure, functional over a wide range of time scales, and characterized by …
GABAA receptor: Positive and negative allosteric modulators
RW Olsen - Neuropharmacology, 2018 - Elsevier
Abstract gamma-Aminobutyric acid (GABA)-mediated inhibitory neurotransmission and the
gene products involved were discovered during the mid-twentieth century. Historically …
gene products involved were discovered during the mid-twentieth century. Historically …
Shared structural mechanisms of general anaesthetics and benzodiazepines
Most general anaesthetics and classical benzodiazepine drugs act through positive
modulation of γ-aminobutyric acid type A (GABAA) receptors to dampen neuronal activity in …
modulation of γ-aminobutyric acid type A (GABAA) receptors to dampen neuronal activity in …
[کتاب][B] Miller's anesthesia, 2-volume set E-book
MA Gropper, LI Eriksson, LA Fleisher… - 2019 - books.google.com
Covering everything from historical and international perspectives to basic science and
current clinical practice, Miller's Anesthesia, 9th Edition, remains the preeminent reference in …
current clinical practice, Miller's Anesthesia, 9th Edition, remains the preeminent reference in …
Crystal structure of a human GABAA receptor
Type-A γ-aminobutyric acid receptors (GABAARs) are the principal mediators of rapid
inhibitory synaptic transmission in the human brain. A decline in GABAAR signalling triggers …
inhibitory synaptic transmission in the human brain. A decline in GABAAR signalling triggers …
Experimental and theoretical approaches to conscious processing
Recent experimental studies and theoretical models have begun to address the challenge of
establishing a causal link between subjective conscious experience and measurable …
establishing a causal link between subjective conscious experience and measurable …
Allosteric modulation as a unifying mechanism for receptor function and regulation
Four major receptor families enable cells to respond to chemical and physical signals from
their proximal environment. The ligand-and voltage-gated ion channels, G-protein-coupled …
their proximal environment. The ligand-and voltage-gated ion channels, G-protein-coupled …
Structural basis of Nav1. 7 inhibition by an isoform-selective small-molecule antagonist
INTRODUCTION Voltage-gated sodium (Nav) channels open and close ion-selective pores
in response to changes in membrane potential, and this gating underlies the generation of …
in response to changes in membrane potential, and this gating underlies the generation of …
Towards a comprehensive understanding of anesthetic mechanisms of action: a decade of discovery
Significant progress has been made in the 21st century towards a comprehensive
understanding of the mechanisms of action of general anesthetics, coincident with progress …
understanding of the mechanisms of action of general anesthetics, coincident with progress …
Ligand binding at the protein–lipid interface: strategic considerations for drug design
Many drug targets are embedded within the phospholipid bilayer of cellular membranes,
including G protein-coupled receptors, ion channels, transporters and membrane-bound …
including G protein-coupled receptors, ion channels, transporters and membrane-bound …