Significance: Extensive research during the last quarter century has revealed that reactive
oxygen species (ROS) produced in the body, primarily by the mitochondria, play a major role …

Although inflammation has long been known as a localized protective reaction of tissue to
irritation, injury, or infection, characterized by pain, redness, swelling, and sometimes loss of …

We have used in vitro and mouse xenograft models to examine the interaction between
breast cancer stem cells (CSC) and bone marrow–derived mesenchymal stem cells (MSC) …

In the United States in the period 1973–1997, the incidence and mortality due to large bowel
cancer was higher in blacks than in other ethnic groups. The incidence in blacks in the …

As sensors for fat-soluble hormones and dietary lipids, oscillations in nuclear receptor (NR)
expression in key metabolic tissues may contribute to circadian entrainment of nutrient and …

It has been recognized for some time that cardiovascular disease and type 2 diabetes are, to
a major extent, inflammatory disorders associated with an environment characterized by a …

The interplay between tumors and their immunologic microenvironment is complex and
difficult to decipher, but its understanding is of seminal importance for the development of …

Neuroinflammatory responses in Alzheimer's disease (AD) are complex and not fully
understood. They involve various cellular and molecular players and associate interaction …

There is increasing evidence that dysregulation of energy homeostasis is associated with
colorectal carcinogenesis. Epidemiological data have consistently demonstrated a positive …

Endometriosis is a frequent disorder that commonly presents with infertility and pelvic pain.
Although the precise aetiology of endometriosis is unclear, it is generally considered to …