The history of enterovirus A71 outbreaks and molecular epidemiology in the Asia-Pacific region

J Puenpa, N Wanlapakorn, S Vongpunsawad… - Journal of biomedical …, 2019 - Springer
Abstract Enterovirus A71 (EV-A71) is one of the common causative pathogens for hand foot
and mouth disease (HFMD) affecting young children. HFMD outbreak can result in a …

World-wide prevalence and genotype distribution of enteroviruses

L Brouwer, G Moreni, KC Wolthers, D Pajkrt - Viruses, 2021 - mdpi.com
Enteroviruses (EVs) are highly prevalent viruses world-wide, causing a wide range of
diseases in both children and adults. Insight in the global prevalence of EVs is important to …

Enterovirus-associated hand-foot and mouth disease and neurological complications in Japan and the rest of the world

G Gonzalez, MJ Carr, M Kobayashi, N Hanaoka… - International journal of …, 2019 - mdpi.com
Enteroviruses (EVs) are responsible for extremely large-scale, periodic epidemics in
pediatric cohorts, particularly in East and Southeast Asia. Clinical presentation includes a …

IRES-targeting small molecule inhibits enterovirus 71 replication via allosteric stabilization of a ternary complex

J Davila-Calderon, NN Patwardhan, LY Chiu… - Nature …, 2020 - nature.com
Abstract Enterovirus 71 (EV71) poses serious threats to human health, particularly in
Southeast Asia, and no drugs or vaccines are available. Previous work identified the stem …

RNA–small-molecule interaction: challenging the “undruggable” tag

J Kaur, A Sharma, P Mundlia, V Sood… - Journal of Medicinal …, 2024 - ACS Publications
RNA targeting, specifically with small molecules, is a relatively new and rapidly emerging
avenue with the promise to expand the target space in the drug discovery field. From being …

Insight into the Enterovirus A71: A review

R Kinobe, A Wiyatno, IM Artika… - Reviews in Medical …, 2022 - Wiley Online Library
Enterovirus A71 is a major causative pathogen of hand, foot and mouth disease. It has
become a global public health threat, and is especially important for infants and young …

Epidemiology and sequence-based evolutionary analysis of circulating non-polio enteroviruses

DM Brown, Y Zhang, RH Scheuermann - Microorganisms, 2020 - mdpi.com
Enteroviruses (EVs) are positive-sense RNA viruses, with over 50,000 nucleotide
sequences publicly available. While most human infections are typically associated with …

Clinical, etiological and epidemiological investigations of hand, foot and mouth disease in southern Vietnam during 2015–2018

LNT Nhan, TH Khanh, NTT Hong… - PLoS neglected …, 2020 - journals.plos.org
Hand, foot and mouth disease (HFMD) continues to challenge Asia with pandemic potential.
In Vietnam, there have been two major outbreaks occurring during 2011–2012 (> 200,000 …

Epidemic curves made easy using the R package incidence

ZN Kamvar, J Cai, JRC Pulliam… - …, 2019 - pmc.ncbi.nlm.nih.gov
The epidemiological curve (epicurve) is one of the simplest yet most useful tools used by
field epidemiologists, modellers, and decision makers for assessing the dynamics of …

Berberine prevents lethal EV71 neurological infection in newborn mice

G Cui, H Wang, C Yang, X Zhou, J Wang… - Frontiers in …, 2022 - frontiersin.org
Enterovirus 71 (EV71) is the major pathogen causing fatal neurological complications of
hand, foot, and mouth disease (HFMD) in young children. Currently no effective antiviral …