Dock family proteins are evolutionary conserved exchange factors for the Rho GTPases Rac
and Cdc42. There are 11 Dock proteins in mammals, named Dock1 (or Dock180) to Dock11 …

Objectives To systematically review findings of GWAS in schizophrenia (SZ) and in bipolar
disorder (BD); and to interpret findings, with a focus on identifying independent replications …

Genetic studies of autism spectrum disorder (ASD) have revealed multigene variations that
converge on synaptic dysfunction. DOCK4, a gene at 7q31. 1 that encodes the Rac1 …

Rac1 is a key regulator of the cytoskeleton and neuronal plasticity, and is known to play a
critical role in psychological and cognitive brain disorders. To elucidate the engram specific …

Abstract Analysis of RNA-seq data often detects numerous 'non-co-linear'(NCL) transcripts,
which comprised sequence segments that are topologically inconsistent with their …

The Rho family GTPases are small G proteins that act as molecular switches shuttling
between active and inactive forms. Rho GTPases are regulated by two classes of regulatory …

Within blood vessels, endothelial cell–cell and cell–matrix adhesions are crucial to preserve
barrier function, and these adhesions are tightly controlled during vascular development …

Bisphenol A (BPA) is an environmental risk factor for autism spectrum disorder (ASD). BPA
exposure dysregulates ASD-related genes in the hippocampus and neurological functions …

GPR34 is a Gi/o protein‐coupled receptor (GPCR) of the nucleotide receptor P2Y12‐like
group. This receptor is highly expressed in microglia, however, the functional relevance of …

Cell‐SELEX can not only generate aptamers for specific cell isolation/detection, diagnosis,
and therapy, but also lead to the discovery of biomarkers and unexpected molecular events …