Conspectus The carbonyl group holds a prominent position in chemistry and biology not
only because it allows diverse transformations but also because it supports key …

The poly-l-proline type II (PPII) helix in recent years has emerged clearly as a structural class
not only of fibrillar proteins (in collagen, PPII is a dominant conformation) but also of the …

Within the canonical repertoire of the amino acid involved in protein biogenesis, proline
plays a unique role as an amino acid presenting a modified backbone rather than a side …

The last 15 years have seen a paradigm shift in our understanding of protein biochemistry,
with the realization that an unexpectedly high fraction of the human genome codes for …

Helices are the most prevalent secondary structure in biomolecules and play vital roles in
their activity. Chemists have been fascinated with mimicking this molecular conformation …

One of the major open challenges in structural biology is to achieve effective descriptions of
disordered states of proteins. This problem is difficult because these states are …

Accurate force fields are essential for the success of molecular dynamics simulations. In
apparent contrast to the conformational preferences of most force fields, recent NMR …

Introduction to Proteins provides a comprehensive and state-of-the-art introduction to the
structure, function, and motion of proteins for students, faculty, and researchers at all levels …

Proteins with intrinsically disordered domains are implicated in a vast range of biological
processes, especially in cell signaling and regulation. Having solved the quaternary …

We seek to understand the link between protein thermodynamics and protein structure in
molecular detail. A classical approach to this problem involves assessing changes in protein …