In this review I summarize interrelations between bioenergetic processes and such
programmed death phenomena as cell suicide (apoptosis and necrosis) and mitochondrial …

Mitochondria are vital cellular organelles involved in a plethora of cellular processes such
as energy conversion, calcium homeostasis, heme biogenesis, regulation of apoptosis and …

Mitochondria form a dynamic network, and it remains unclear how the alternate
configurations interact with bioenergetics properties. The metabolic signals that link …

Mitochondrial dysfunction is linked to apoptosis, aging, cancer, and a number of
neurodegenerative and muscular disorders. The interplay between mitophagy and …

Many muscular and neurological disorders are associated with mitochondrial dysfunction
and are often accompanied by changes in mitochondrial morphology. Mutations in the gene …

Highlights•H/I lead to mitochondria fission in pMCAO rats and OGD PC12 cells.•H/I lead to
mitochondria fission and mitophagy at the early stage of injury.•Inhibition of Drp1 selectively …

Mitochondria are indispensable cellular organelles providing ATP and numerous other
essential metabolites to ensure cell survival. Reactive oxygen species (ROS), which are …

Dysfunctional mitochondria show a reduced capacity for fusion and, as mitochondrial fission
is maintained, become spatially separated from the intact network. By that mechanism …

The ring-substituted derivatives of carbonyl cyanide phenylhydrazone, CCCP and FCCP,
are routinely used for the analysis of the mitochondrial function in living cells, tissues, and …

Fission of the mitochondrial reticulum (the thread–grain transition) and following gathering of
mitochondria in the perinuclear area are induced by oxidative stress. It is shown that …