Revisiting the role of ABC transporters in multidrug-resistant cancer
Most patients who die of cancer have disseminated disease that has become resistant to
multiple therapeutic modalities. Ample evidence suggests that the expression of ATP …
multiple therapeutic modalities. Ample evidence suggests that the expression of ATP …
Targeting multidrug resistance in cancer
G Szakács, JK Paterson, JA Ludwig… - Nature reviews Drug …, 2006 - nature.com
Effective treatment of metastatic cancers usually requires the use of toxic chemotherapy. In
most cases, multiple drugs are used, as resistance to single agents occurs almost …
most cases, multiple drugs are used, as resistance to single agents occurs almost …
Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line
SPC Cole, G Bhardwaj, JH Gerlach, JE Mackie… - Science, 1992 - science.org
The doxorubicin-selected lung cancer cell line H69AR is resistant to many
chemotherapeutic agents. However, like most tumor samples from individuals with this …
chemotherapeutic agents. However, like most tumor samples from individuals with this …
Evolutionary dynamics of carcinogenesis and why targeted therapy does not work
RJ Gillies, D Verduzco, RA Gatenby - Nature Reviews Cancer, 2012 - nature.com
All malignant cancers, whether inherited or sporadic, are fundamentally governed by
Darwinian dynamics. The process of carcinogenesis requires genetic instability and highly …
Darwinian dynamics. The process of carcinogenesis requires genetic instability and highly …
Transmembrane transport of endo-and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins
Multidrug Resistance Proteins (MRPs), together with the cystic fibrosis conductance
regulator (CFTR/ABCC7) and the sulfonylurea receptors (SUR1/ABCC8 and SUR2/ABCC9) …
regulator (CFTR/ABCC7) and the sulfonylurea receptors (SUR1/ABCC8 and SUR2/ABCC9) …
ABC efflux pump-based resistance to chemotherapy drugs
Over 1 million new cases of all types of cancer are diagnosed each year in the United States
alone, and 559 650 cancer-related deaths were expected to occur in 2007. 1 …
alone, and 559 650 cancer-related deaths were expected to occur in 2007. 1 …
The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates.
I Leier, G Jedlitschky, U Buchholz, SPC Cole… - Journal of Biological …, 1994 - Elsevier
The multidrug resistance-associated protein (MRP) is the product of an ATP-binding
cassette transporter gene overexpressed in some tumor cells resistant to antineoplastic …
cassette transporter gene overexpressed in some tumor cells resistant to antineoplastic …
Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells
SPC Cole, KE Sparks, K Fraser, DW Loe, CE Grant… - Cancer research, 1994 - AACR
We have previously identified and characterized a novel member of the ATP-binding
cassette superfamily of transport proteins, multidrug resistance protein (MRP), and …
cassette superfamily of transport proteins, multidrug resistance protein (MRP), and …
The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump.
GJ Zaman, MJ Flens… - Proceedings of the …, 1994 - National Acad Sciences
The multidrug-resistance associated protein MRP is a 180-to 195-kDa membrane protein
associated with resistance of human tumor cells to cytotoxic drugs. We have investigated …
associated with resistance of human tumor cells to cytotoxic drugs. We have investigated …
Overexpression of multidrug resistance-associated protein (MRP) increases resistance to natural product drugs
CE Grant, G Valdimarsson, DR Hipfner, KC Almquist… - Cancer research, 1994 - AACR
Amplification of the gene encoding multidrug resistance-associated protein (MRP) and
overexpression of its cognate mRNA have been detected in multidrug-resistant cell lines …
overexpression of its cognate mRNA have been detected in multidrug-resistant cell lines …