Targeted drugs have changed cancer treatment but are often ineffective in the long term
against solid tumours, largely because of the activation of heterogeneous oncogenic …

Pin1 is the only known peptidyl-prolyl cis–trans isomerase (PPIase) that specifically
recognizes and isomerizes the phosphorylated Serine/Threonine-Proline (pSer/Thr-Pro) …

Multisite phosphorylation modulates the function of regulatory proteins with complex
signaling properties and outputs. The retinoblastoma tumor suppressor protein (Rb) is …

Proline-directed phosphorylation is a posttranslational modification that is instrumental in
regulating signaling from the plasma membrane to the nucleus, and its dysregulation …

The prolyl isomerase PIN1, a critical modifier of multiple signalling pathways, is
overexpressed in the majority of cancers and its activity strongly contributes to tumour …

Peptidyl-prolyl cis/trans isomerase family (PPIase) is structurally divided into three
subfamilies, cyclophilins (Cyps), FK506-binding proteins (FKBPs), and parvulins. Pin1 …

In yeast, the glucose-induced degradation-deficient (GID) E3 ligase selectively degrades
superfluous gluconeogenic enzymes. Here, we identified all subunits of the mammalian …

Human papillomavirus (HPV) is implicated in over 90% of cervical cancer cases, with factors
like regional variability, HPV genotype, the population studied, HPV vaccination status, and …

Cell cycle progression is tightly controlled by many cell cycle-regulatory proteins that are in
turn regulated by a family of cyclin-dependent kinases (CDKs) through protein …

Cellular senescence increases with aging. While senescence is associated with an exit of
the cell cycle, there is ample evidence that post-mitotic cells including neurons can undergo …