[HTML][HTML] Clonal dynamics of haematopoiesis across the human lifespan
E Mitchell, M Spencer Chapman, N Williams… - Nature, 2022 - nature.com
Age-related change in human haematopoiesis causes reduced regenerative capacity,
cytopenias, immune dysfunction and increased risk of blood cancer,–, but the reason for …
cytopenias, immune dysfunction and increased risk of blood cancer,–, but the reason for …
Clonal hematopoiesis is associated with risk of severe Covid-19
Acquired somatic mutations in hematopoietic stem and progenitor cells (clonal
hematopoiesis or CH) are associated with advanced age, increased risk of cardiovascular …
hematopoiesis or CH) are associated with advanced age, increased risk of cardiovascular …
Somatic mosaicism in biology and disease
H Ogawa, K Horitani, Y Izumiya… - Annual review of …, 2022 - annualreviews.org
Contrary to earlier beliefs, every cell in the individual is genetically different due to somatic
mutations. Consequently, tissues become a mixture of cells with distinct genomes, a …
mutations. Consequently, tissues become a mixture of cells with distinct genomes, a …
To portray clonal evolution in blood cancer, count your stem cells
Clonal evolution, the process of expansion and diversification of mutated cells, plays an
important role in cancer development, resistance, and relapse. Although clonal evolution is …
important role in cancer development, resistance, and relapse. Although clonal evolution is …