Legal aspects of privacy-enhancing technologies in genome-wide association studies and their impact on performance and feasibility

A Brauneck, L Schmalhorst, S Weiss, L Baumbach… - Genome Biology, 2024‏ - Springer
Genomic data holds huge potential for medical progress but requires strict safety measures
due to its sensitive nature to comply with data protection laws. This conflict is especially …

Ensuring privacy and security of genomic data and functionalities

A Mohammed Yakubu, YPP Chen - Briefings in bioinformatics, 2020‏ - academic.oup.com
In recent times, the reduced cost of DNA sequencing has resulted in a plethora of genomic
data that is being used to advance biomedical research and improve clinical procedures …

A prospective analysis of genetic variants associated with human lifespan

KM Wright, KA Rand, A Kermany, K Noto… - G3: Genes …, 2019‏ - academic.oup.com
We present a massive investigation into the genetic basis of human lifespan. Beginning with
a genome-wide association (GWA) study using a de-identified snapshot of the unique …

Using game theory to thwart multistage privacy intrusions when sharing data

Z Wan, Y Vorobeychik, W **a, Y Liu, M Wooders… - Science …, 2021‏ - science.org
Person-specific biomedical data are now widely collected, but its sharing raises privacy
concerns, specifically about the re-identification of seemingly anonymous records. Formal re …

Big genetic data and its big data protection challenges

P Quinn, L Quinn - Computer law & security review, 2018‏ - Elsevier
The use of various forms of big data have revolutionised scientific research. This includes
research in the field of genetics in areas ranging from medical research to anthropology …

The goldmine of GWAS summary statistics: a systematic review of methods and tools

PI Kontou, PG Bagos - BioData Mining, 2024‏ - Springer
Genome-wide association studies (GWAS) have revolutionized our understanding of the
genetic architecture of complex traits and diseases. GWAS summary statistics have become …

Beyond genes: Re-identifiability of proteomic data and its implications for personalized medicine

K Boonen, K Hens, G Menschaert, G Baggerman… - Genes, 2019‏ - mdpi.com
The increasing availability of high throughput proteomics data provides us with opportunities
as well as posing new ethical challenges regarding data privacy and re-identifiability of …

Large-scale privacy-preserving statistical computations for distributed genome-wide association studies

O Tkachenko, C Weinert, T Schneider… - Proceedings of the 2018 …, 2018‏ - dl.acm.org
We present privacy-preserving solutions for Genome-Wide Association Studies (GWAS)
based on Secure Multi-Party Computation (SMPC). Using SMPC, we protect the privacy of …

Methods of privacy-preserving genomic sequencing data alignments

D Lu, Y Zhang, L Zhang, H Wang… - Briefings in …, 2021‏ - academic.oup.com
Genomic data alignment, a fundamental operation in sequencing, can be utilized to map
reads into a reference sequence, query on a genomic database and perform genetic tests …

Digital dna lifecycle security and privacy: an overview

MM Alsaffar, M Hasan, GP McStay… - Briefings in …, 2022‏ - academic.oup.com
DNA sequencing technologies have advanced significantly in the last few years leading to
advancements in biomedical research which has improved personalised medicine and the …