MicroRNAs (miRNAs) are∼ 22 nt RNAs that direct posttranscriptional repression of mRNA
targets in diverse eukaryotic lineages. In humans and other mammals, these small RNAs …

Our vasculature plays diverse and critical roles in homeostasis and disease. In recent
decades, the use of zebrafish has driven our understanding of vascular development into …

Definitive haematopoietic stem and progenitor cells (HSPCs) generate erythroid, lymphoid
and myeloid lineages. HSPCs are produced in the embryo via transdifferentiation of …

MicroRNAs (miRNAs) contribute to the progressive changes in gene expression that occur
during development. The combined loss of all miRNAs results in embryonic lethality in all …

Multicellularity has coincided with the evolution of microRNAs (miRNAs), small regulatory
RNAs that are integrated into cellular differentiation and homeostatic gene-regulatory …

Intracranial aneurysm (IA) rupture leads to subarachnoid hemorrhage, a sudden-onset
disease that often causes death or severe disability. Although genome-wide association …

MicroRNA-223 is known as a myeloid-enriched anti-inflammatory microRNA that is
dysregulated in numerous inflammatory conditions. Here, we report that neutrophilic …

Emerging evidence indicates that angiopoietin-2 (Angpt2), a well-recognized vascular
destabilizing factor, is a biomarker of poor outcome in ischemic heart disease. However, its …

Tendon injuries are one of the most common musculoskeletal disorders that cause
considerable morbidity and significantly compromise the patients' quality of life. The innate …

Canalization, or robustness to genetic or environmental perturbations, is fundamental to
complex organisms. While there is strong evidence for canalization as an evolved property …