Studies in mammals and Drosophila have demonstrated the existence and significance of
secreted factors involved in communication between distal organs. In this review, primarily …

In the last decade, RNA interference (RNAi), a cellular mechanism that uses RNA-guided
degradation of messenger RNA transcripts, has had an important impact on identifying and …

To facilitate large-scale functional studies in Drosophila, the Drosophila Transgenic RNAi
Project (TRiP) at Harvard Medical School (HMS) was established along with several goals …

Complex regulatory networks regulate stem cell behavior and contributions to tissue growth,
repair, and homeostasis. A full understanding of the networks controlling stem cell self …

Gametes are highly specialized cell types produced by a complex differentiation process.
Production of viable oocytes requires a series of precise and coordinated molecular events …

Abstract N6-methyladenosine (m6A), the most abundant internal modification in eukaryotic
mRNA, is installed by a multi-component writer complex; however, the exact roles of each …

The differentiation of stem cells is a tightly regulated process essential for animal
development and tissue homeostasis. Through this process, attainment of new identity and …

Drosophila oogenesis is an excellent system for the study of developmental cell biology.
Active areas of research include stem cell maintenance, gamete development, pattern …

The long-term survival of any multicellular species depends on the success of its germline in
producing high-quality gametes and maximizing survival of the offspring. Studies in …

The intestinal epithelium is the most rapidly self-renewing tissue in adult animals and
maintained by intestinal stem cells (ISCs) in both Drosophila and mammals. To …