Acylcarnitines are fatty acid metabolites that play important roles in many cellular energy
metabolism pathways. They have historically been used as important diagnostic markers for …

Tumors undergo metabolic transformations to sustain uncontrolled proliferation, avoid cell
death, and seed in secondary organs. An increased focus on cancer lipid metabolism has …

Exposure of lipopolysaccharide triggers macrophage pro-inflammatory polarization
accompanied by metabolic reprogramming, characterized by elevated aerobic glycolysis …

Metabolism is a major regulator of immune cell function, but it remains difficult to study the
metabolic status of individual cells. Here, we present Compass, an algorithm to characterize …

Abstract Changes in mitochondrial morphology are associated with nutrient utilization, but
the precise causalities and the underlying mechanisms remain unknown. Here, using …

Through the successes of checkpoint blockade and adoptive cellular therapy,
immunotherapy has become an established treatment modality for cancer. Cellular …

Characterized by the expression of the critical transcription factor forkhead box protein P3,
regulatory T (Treg) cells are an essential part of the immune system, with a dual effect on the …

Macrophages are cells of the innate immune system that regulate the maintenance of tissue
homeostasis, host defense during pathogen infection, and tissue repair in response to tissue …

Immune cells' metabolism influences their differentiation and function. Given that a complex
interplay of environmental factors within the tumor microenvironment (TME) can have a …

Macrophage activation is intimately linked to metabolic reprogramming. Inflammatory (M1)
macrophages are able to sustain inflammatory responses and to kill pathogens, mostly by …