While largely neglected over decades during which adaptive immunity captured most of the
attention, innate immune mechanisms have now become central to our understanding of …

The immune system enables organisms to combat infections and to eliminate endogenous
challenges. Immune responses can be evoked through diverse inducible pathways …

Loss of RNA homeostasis underlies numerous neurodegenerative and neuroinflammatory
diseases. However, the molecular mechanisms that trigger neuroinflammation are poorly …

Cancer stem cells (CSCs) are a subpopulation of cancer cells endowed with high
tumorigenic, chemoresistant and metastatic potential. Nongenetic mechanisms of acquired …

Successful pregnancy requires carefully-coordinated communications between the mother
and fetus. Immune cells and cytokine signaling pathways participate as mediators of these …

The characterization of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
viral kinetics in hospitalized patients and its association with mortality is unknown. We …

Abstract The coronavirus disease 2019 (COVID-19) triggered by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) erupted in Hubei Province of China in December …

The severe respiratory consequences of the coronavirus disease 2019 (COVID-19)
pandemic have prompted urgent need for novel therapies. Cell-based approaches, primarily …

Type I interferon (IFN) is produced when host sensors detect foreign nucleic acids, but how
sensors differentiate self from nonself nucleic acids, such as double-stranded RNA (dsRNA) …

Thymus is necessary for lifelong immunological tolerance and immunity. It displays a
distinctive epithelial complexity and undergoes age-dependent atrophy. Nonetheless, it also …