Alzheimer's disease (AD) is a genetically complex and heterogeneous disorder with
multifaceted neuropathological features, including β-amyloid plaques, neurofibrillary …

The severe cases of Coronavirus Disease 2019 (COVID-19) frequently exhibit excessive
inflammatory responses, acute respiratory distress syndrome (ARDS), coagulopathy, and …

Inflammatory bowel disease (IBD) is a chronic inflammatory intestinal disorder that is difficult
to cure and characterized by periods of relapse. To face the challenges of limited treatment …

Immune checkpoint inhibitors (ICIs), including anti-CTLA-4 (cytotoxic T lymphocyte antigen-
4) and anti-PD-1/PD-L1 (programmed death-1/programmed death-ligand 1), represent a …

Acidic organelles act as intracellular Ca 2+ stores; they actively sequester Ca 2+ in their
lumina and release it to the cytosol upon activation of endo-lysosomal Ca 2+ channels …

In recent years, our understanding of the structure, mechanisms and functions of the endo-
lysosomal TPC (two-pore channel) family have grown apace. Gated by the second …

Abstract CD4+ Foxp3+ regulatory T cells (Tregs), a subpopulation of CD4+ T cells, are
engaged in maintaining the periphery tolerance and preventing autoimmunity. Recent …

There is compelling evidence that CD4+ Foxp3+ regulatory T cells (Tregs) are
indispensable in the inhibition of autoimmune inflammatory responses, including psoriasis …

Inflammation can be triggered by any factor. The primary pathological manifestations can be
summarized as the deterioration, exudation, and proliferation of local tissues, which can …

One characteristic of tumor-associated CD4+ Foxp3+ regulatory T cells (Tregs) is the high
expression of tumor necrosis factor receptor type II (TNFR2), a receptor that mediates the …