Multiple sclerosis (MS) is the most frequent chronic inflammatory disease of the CNS, and
imposes major burdens on young lives. Great progress has been made in understanding …

Reproducible science requires transparent reporting. The ARRIVE guidelines (Animal
Research: Reporting of In Vivo Experiments) were originally developed in 2010 to improve …

Improving the reproducibility of biomedical research is a major challenge. Transparent and
accurate reporting is vital to this process; it allows readers to assess the reliability of the …

Multiple sclerosis (MS) has long been regarded as a chronic inflammatory disease of the
white matter that leads to demyelination and eventually to neurodegeneration. In the past …

Background Data from multiple sclerosis (MS) and the MS rodent model, experimental
autoimmune encephalomyelitis (EAE), highlighted an inflammation-dependent …

Aging is one of the main risk factors for the development of many neurodegenerative
diseases. Emerging evidence has acknowledged neuroinflammation as potential trigger of …

Animal models of multiple sclerosis (MS), specifically experimental autoimmune
encephalomyelitis (EAE), have been used extensively to develop anti-inflammatory …

Background: Chronic inflammation leads to gray matter damage in progressive multiple
sclerosis (MS), but the mechanism linking inflammation and neurodegeneration is unclear …

Cerebellar deficit contributes significantly to disability in multiple sclerosis (MS). Several
clinical and experimental studies have investigated the pathophysiology of cerebellar …

Glutamate is the major excitatory neurotransmitter in the nervous system, where it induces
multiple beneficial and essential effects. Yet, excess glutamate, evident in a kaleidoscope of …