[PDF][PDF] Understanding eukaryotic linear motifs and their role in cell signaling and regulation
Introduction 3. Complex and cooperative–Signal integration and deterministic signaling 3.1.
Interactions as descriptors of protein function 3.2. Cooperative binding of linear motifs 3.3 …
Interactions as descriptors of protein function 3.2. Cooperative binding of linear motifs 3.3 …
ELM server: a new resource for investigating short functional sites in modular eukaryotic proteins
Multidomain proteins predominate in eukaryotic proteomes. Individual functions assigned to
different sequence segments combine to create a complex function for the whole protein …
different sequence segments combine to create a complex function for the whole protein …
Short linear motifs in colorectal cancer interactome and tumorigenesis
C Fasano, V Grossi, G Forte, C Simone - Cells, 2022 - mdpi.com
Colorectal tumorigenesis is driven by alterations in genes and proteins responsible for
cancer initiation, progression, and invasion. This multistage process is based on a dense …
cancer initiation, progression, and invasion. This multistage process is based on a dense …
ELM: the status of the 2010 eukaryotic linear motif resource
Linear motifs are short segments of multidomain proteins that provide regulatory functions
independently of protein tertiary structure. Much of intracellular signalling passes through …
independently of protein tertiary structure. Much of intracellular signalling passes through …
SLiMSearch: a framework for proteome-wide discovery and annotation of functional modules in intrinsically disordered regions
I Krystkowiak, NE Davey - Nucleic acids research, 2017 - academic.oup.com
The extensive intrinsically disordered regions of higher eukaryotic proteomes contain vast
numbers of functional interaction modules known as short linear motifs (SLiMs). Here, we …
numbers of functional interaction modules known as short linear motifs (SLiMs). Here, we …
SeqNLS: nuclear localization signal prediction based on frequent pattern mining and linear motif scoring
Nuclear localization signals (NLSs) are stretches of residues in proteins mediating their
importing into the nucleus. NLSs are known to have diverse patterns, of which only a limited …
importing into the nucleus. NLSs are known to have diverse patterns, of which only a limited …
Molecular switches involving the AP-2 β2 appendage regulate endocytic cargo selection and clathrin coat assembly
Clathrin-associated sorting proteins (CLASPs) expand the repertoire of endocytic cargo
sorted into clathrin-coated vesicles beyond the transmembrane proteins that bind physically …
sorted into clathrin-coated vesicles beyond the transmembrane proteins that bind physically …
Mechanisms of zoonotic severe acute respiratory syndrome coronavirus host range expansion in human airway epithelium
T Sheahan, B Rockx, E Donaldson, A Sims… - Journal of …, 2008 - Am Soc Microbiol
In 2003, severe acute respiratory syndrome coronavirus (SARS-CoV) emerged and caused
over 8,000 human cases of infection and more than 700 deaths worldwide. Zoonotic SARS …
over 8,000 human cases of infection and more than 700 deaths worldwide. Zoonotic SARS …
PSSMSearch: a server for modeling, visualization, proteome-wide discovery and annotation of protein motif specificity determinants
There is a pressing need for in silico tools that can aid in the identification of the complete
repertoire of protein binding (SLiMs, MoRFs, miniMotifs) and modification (moiety …
repertoire of protein binding (SLiMs, MoRFs, miniMotifs) and modification (moiety …
SLiMSearch 2.0: biological context for short linear motifs in proteins
Short, linear motifs (SLiMs) play a critical role in many biological processes. The
SLiMSearch 2.0 (Short, Linear Motif Search) web server allows researchers to identify …
SLiMSearch 2.0 (Short, Linear Motif Search) web server allows researchers to identify …